Abstract
Serum cholinesterase activities were measured for 270 minutes in patients following administration of neostigmine or pyridostigmine for the reversal of pancuronium block in groups of seven patients each. The enzyme activities were significantly depressed by neostigmine for four hours and by pyridostigmine throughout the whole period of study. Whereas the immediate effects of neostigmine were more intense, the effects of pyridostigmine beyond the first 30 minutes were more profound. The clinical relevance of these findings is discussed.
Résumé
On a mesuré l’activité de la cholinestérase sérique durant 270 minutes après l’administration de néostigmine ou de pyridostigmine, ces agents étant utilisés pour lever un bloc au pancuronium. Deux groupes de sept patients chacun ont été étudiés, ceux du premier groupe ayant reçu de la néostigmine et ceux du second groupe de la pyridostigmine. L’activité de la cholinestérase était significativement diminuée durant quatre heures après l’administration de néostigmine et durant toute la durée de l’étude (270 minutes) dans le cas de la pyridostigmine. Les effets immédiats de la néostigmine étaient plus marqués que ceux de la pyridostigmine. Trente minutes après son administration, ceux de la pyridostigmine étaient plus importants. Les applications cliniques de ces résultats sont discutées.
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Mirakhur, R.K., Lavery, T.D., Briggs, L.P. et al. Effects of neostigmine and pyridostigmine on serum cholinesterase activity. Canad. Anaesth. Soc. J. 29, 55–58 (1982). https://doi.org/10.1007/BF03007949
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DOI: https://doi.org/10.1007/BF03007949