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Urinary elimination of free phenolphthalein no test for gastro-intestinal ulceration

  • Published:
The American Journal of Digestive Diseases

Conclusions

  1. 1.

    Free phenolphthalein generally appears in the urine whenever the quantity of conjugated phenolphthalein in any one specimen exceeds 5 mg. per 100 cc. of urine.

  2. 2.

    In some abnormal individuals, e.g. cardiac, renal cases and blood dyscrasias, free phenolphthalein appears at an even lower concentration than 5 mg. per cent.

  3. 3.

    Quite a proportion of pathologic non-ulcer cases and of normal individuals obtain such concentration after the ingestion of 0.1 Gm. of phenolphthalein in 10 cc. of 95% alcohol.

  4. 4.

    Hence the appearance of free phenolphthalein in the urine cannot be considered a diagnostic test for gastro-intestinal ulceration.

  5. 5.

    The dose of phenolphthalein used in this study produced a laxative effect in 80% of the normal cases and in 44.4% of the patients thus studied. We wish to express our sincerest thanks to Dr. Bernard Pantus who has been of inestimable help to us in the preparation of this paper.

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References

  1. Marks, M. B.: Permeability to Egg Albumin in Peptic Ulcer Possible Test for Activity of Peptic Ulcers. Preliminary Report.Am. J. Dig. Dis. and Nutrit., 3:41–44, March, 1936.

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  2. Woldman, Edward E.: A Simple Test for Determining the Presence of Gastro-Intestinal Lesions. A Preliminary Report.Am. J. Dig. Dis., 5:221, June, 1938.

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  3. Fantus, Bernard and Dyniewicz, J. M.: Phenolphthalein Studies. Elimination of Phenolphthalein.J. A. M. A., 110:796–799, March 12, 1938.

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Authors and Affiliations

  1. Department of Medicine, Cook County Hospital, Chicago

    F. Steigmann & J. M. Dyniewicz

  2. Department of Medicine, Laboratory of Pharmacology and Therapeutics, Chicago

    F. Steigmann & J. M. Dyniewicz

  3. University of Illinois, College of Medicine, Chicago, Illinois

    F. Steigmann & J. M. Dyniewicz

Authors
  1. F. Steigmann
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  2. J. M. Dyniewicz
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Steigmann, F., Dyniewicz, J.M. Urinary elimination of free phenolphthalein no test for gastro-intestinal ulceration. American Journal of Digestive Diseases 6, 120–122 (1939). https://doi.org/10.1007/BF03007934

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  • DOI: https://doi.org/10.1007/BF03007934

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