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Histological Study of Hypervitaminosis D

The Relative Toxicity of the Vitamin D of Irradiated Ergosterol and Tuna Liver Oil

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The American Journal of Digestive Diseases

Summary

It has been possible to show by this series of tests that the ingestion by the rat of large amounts of Vitamin D in the form of tuna liver oil or tuna liver oil concentrate will cause calcification of certain tissues.

The Vitamin D of irradiated ergosterol is definitely more tissue-calcifying than the Vitamin D of tuna liver oil. The calcification produced by feeding 50,000 units of irradiated ergosterol daily was more severe than that resulting from the feeding of 80,000 units of tuna liver oil concentrate daily.

Similar experiments are now being made, using a chemical, rather than a histological, technique to measure the hypervitaminic effect.

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References

  1. Pfannenstiel, W.: The Effects of Irradiated Ergosterol in Animal Experiments.Munch. Med. Wochschr., 75: 111, 1928.

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Authors and Affiliations

  1. Biological Research Laboratories, Massachusetts Institute of Technology, Cambridge, Massachusetts

    Robert S. Harris, Bernard D. Ross & John W. M. Bunker

Authors
  1. Robert S. Harris
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  2. Bernard D. Ross
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  3. John W. M. Bunker
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Harris, R.S., Ross, B.D. & Bunker, J.W.M. Histological Study of Hypervitaminosis D. American Journal of Digestive Diseases 6, 81–83 (1939). https://doi.org/10.1007/BF03007922

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  • DOI: https://doi.org/10.1007/BF03007922

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