Abstract
This study was done to evaluate the potential role of plasma glycine levels as an indicator of the biochemical changes occurring during or shortly after transurethral resection of the prostate (TURP). Seventeen patients undergoing TURP were studied to determine the fate of the absorbed glycine and its effects on other amino acids and their relationship to changes in serum sodium and osmolarity. Twelve patients showed more than 100 per cent increase in plasma glycine levels with values ranging to more than 100-fold elevation. Only two patients showed a change in serum sodium of greater than 10mEqll with corresponding change in osmolarity. In one such patient there was no accompanying change in plasma glycine. Thus, major changes in plasma glycine and serum sodium may occur independently of one another, and may separately account for manifestations of the reactions following TURP.
Résumé
Cette étude a été entreprise pour évaluer le rôle possible des concentrations plasmatiques de glycine comme indicateur des changements biochimiques survenant durant ou immédiatement après la résection de la prostate par vote trans-urétrale. Dix-sept patients soumis à cette chirurgie out été étudiés; on a suivi la destinée de la glycine absorbée et observé ses effets sur les autres amino-acides de même que sa corrélation avec les ckangements de la natrémie et l’ osmolarité. Chez 12 malades on a observé une augmentation de 100 pour cent des niveaux plasma-tiques de glycine avec certaines valeurs extrêmes allant jusqu’au centuple de la concentration de départ. Chez deiix patients settlement a-i-on observé un changement de la natrémie plus grand que 10mEq accompagné d’une modification d’osmolarite dans le même sens. Chez un de ces malades il n’y a eu aucune modification de la glycine plasmadque. Ainsi, on pent voir que des modifications importantes des niveaux plasmatiques de glycine et de la natremie peuvent survenir indépendamment l’une de l’autre et peuvent, chacune pour son propre compte, expliquer les réactions qu’on observe à la suite de prostatectomie trans-urétrale.
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Zucker, J.R., Bull, A.P. Independent plasma levels of sodium and glycine during transurethral resection of the prostate. Can Anaesth Soc J 31, 307–313 (1984). https://doi.org/10.1007/BF03007896
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DOI: https://doi.org/10.1007/BF03007896