Abstract
Some of the effects of inhalational anaesthetics may be mediated by (3-endorphins acting on opioid receptors. Stimulation of such receptors has been shown both to promote and to inhibit the release of arginine vasopressin (AVP). Ten rabbits were studied to determine the response of plasma AVP to a predetermined time/concentration “dose” of halothane, enflurane or isoflurane. Abolition of corneal reflex was used as a standard end-point. Plasma samples were obtained from awake animals and after exposure to the anaesthetics, the sequence being randomly assigned. No significant changes in plasma AVP concentrations were observed when predetermined time/concentration “doses” of the agents were administered to the rabbits. Anaesthesia produced by halothane, enflurane or isoflurane, therefore, is not necessarily accompanied by changes in plasma AVP.
Résumé
Certains effets de l’anesthésie par inhalation pourraient être obtenus par mVdiation des β-endorphines sur les récepteurs opioïdes. II a déjà été démontré que la stimulation de ces réeurs provoque et inhibe la libération de l’arginine-vasopressine (AVP). L’étude a porté sur dix lapins et avail pour but d’évaluer la réponse de l’AVP plasmatique à une exposition prédémp;erminée d’halothane, d’enflurane ou d’isoflurane. L’abolition du réflexe coméen a été le critère recherché pour 1’arrêt de l’expérience. En séquence randomiséed, des spécimens de plasma ont été pré1evés sur les animaux éveillés et après exposition aux anesthésiques. On n’a observé aucune modification des concentrations plasmatiques d’AVP. L’anesthésie produite par 1’halothane, l’enflurane ou l’isoflurane ne s’accompagne done pas nécessairement de changements d’AVP plasmatique.
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An erratum to this article is available at http://dx.doi.org/10.1007/BF03009338.
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Leighton, K.M., Lim, S.L. & Wilson, N. Arginine vasopressin response to anaesthesia produced by halothane, enflurane and isoflurane. Canad. Anaesth. Soc. J. 29, 563–566 (1982). https://doi.org/10.1007/BF03007741
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DOI: https://doi.org/10.1007/BF03007741