Summary
All is not bleak as to the future of RNA, but to do it right, we need to approach it based on evidence gleaned from well-conducted clinical studies. Only then will we determine the added value of exercise EF over MPI in patient management.
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Blumgart HL, Weiss S. Studies on the velocity of blood flow: VII. The pulmonary circulation time in normal resting individuals. J Clin Invest 1927;4:399–425.
Borer JS, Bacharach SL, Green MV, Kent KM, Epstein SE, Johnston GS. Real-time radionuclide cineangiography in the noninvasive evaluation of global and regional left ventricular function at rest and during exercise in patients with coronary artery disease. N Engl J Med 1977;296:839–44.
Jengo JA, Oren V, Conant R, Brizendine M, Nelson T, Uszler JM, et al. Effects of maximal exercise stress on left ventricular function in patients with coronary artery disease using first pass radionuclide angiocardiography: A rapid, noninvasive technique for determining ejection fraction and segmental wall motion. Circulation 1979;59:60–5.
Friedman JD, Berman DS, Borges-Neto S, Hayes SW, Johnson LL, Nichols KJ, et al. First-pass radionuclide angiography. J Nucl Cardiol 2006;13:e42–55.
Iskandrian AE, Garcia EV, editors. Nuclear cardiac imaging: Principles and applications. 4th ed. New York: Oxford University Press; 2008.
Iskandrian AS, Hakki AH, Goel IP, Mundth ED, Kane-Marsch SA, Schenk CL. The use of rest and exercise radionuclide ventriculography in risk stratification in patients with suspected coronary artery disease. Am Heart J 1985;110:864–72.
Jones EH, Johnson SH, Bigelow C, et al. Exercise radionuclide angiocardiography predicts cardiac death in patients with coronary artery disease. Circulation 1991;84(Suppl):I52–8.
Shaw LJ, Heinle SK, Borges-Neto S, Kesler K, Coleman RE, Jones RH. Prognosis by measurements of left ventricular function during exercise. Duke Non-invasive Research Working Group. J Nucl Med 1998;39:140–6.
Mast ST, Shaw LK, Ravizzini GC, Chambless M, Joski P, Coleman RE, et al. Incremental prognostic value of RNA ejection fraction measurements during pharmacologic stress testing; A comparison with clinical and perfusion variables. J Nucl Med 2001;42:871–7.
Liao L, Smith WT, Tuttle RH, Shaw LK, Coleman RE, Borges-Neto S. Predication of death and nonfatal myocardial infarction in high-risk patients: A comparison between the Duke treadmill score, peak exercise radionuclide angiography, and SPECT perfusion imaging. J Nucl Med 2005;46:5–11.
Lee KL, Pryor DB, Pieper KS, Harrell FE Jr, Califf RM, Mark DB, et al. Prognostic value of radionuclide angiography in medically treated patients with coronary artery disease. A comparison with clinical and catheterization variables. Circulation 1990;82:1705–17.
Borges-Neto S, Shaw LJ, Kesler KL, Hanson MW, Peterson ED, Morris EI, et al. Prediction of severe coronary artery disease by combined rest and exercise radionuclide angiocardiography and tomographic perfusion imaging with technetium 99m-labeled sestamibi: A comparison with clinical and electrocardiographic data. J Nucl Cardiol 1997;4:189–94.
Flamen P, Dendale P, Bossuyt A, Franken PR. Combined left ventricular wall motion and myocardial perfusion stress imaging in the initial assessment of patients with a recent myocardial infarction. Angiology 1995;46:461–72.
Heo J, Htay T, Mehta D, Sun L, Lacy J, Iskandrian AE. Assessment of left ventricular function during upright treadmill exercise with tantalum 178 and multiwire gamma camera. J Nucl Cardiol 2005;12:560–6.
Bonow RO. Radionuclide angiography in the management of asymptomatic aortic regurgitation. Circulation 1991;84(Suppl): 1296–302.
Bonow RO. Radionuclide angiographic evaluation of left ventricular diastolic function. Circulation 1991;84(Suppl):1208–15.
Port SC. Recent advances in first-pass radionuclide angiography. Cardiol Clin 1994;12:359–72.
Zafrir N, Zingerman B, Solodky A, Ben-Dayan D, Sagie A, Sulkes J, et al. Use of noninvasive tools in primary pulmonary hypertension to assess the correlation of right ventricular function with functional capacity and to predict outcome. Int J Cardiovasc Imaging 2007;23:209–15.
Johnson LL, Lawson MA, Blackwell GG, Tauxe EL, Russell K, Dell’Italia LJ. Optimizing the method to calculate right ventricular ejection from first-pass data acquired with a multicrystal camera. J Nucl Cardiol 1995;2:372–9.
Santana CA, Shaw LJ, Garcia EV, Soler-Peter M, Candell-Riera J, Grossman GB, et al. Incremental prognostic value of left ventricular function by myocardial gated FDG PET imaging in patients with ischemic cardiomyopathy. J Nucl Cardiol 2004;11:542–50.
Dorbala S, Vangala D, Sampson U, Limaye A, Kwong R, Di Carli MF. Value of vasodilator left ventricular ejection fraction reserve in evaluating the magnitude of myocardium at risk and the extent of angiographic coronary artery disease: A 82Rb PET/CT study. J Nucl Med 2007;48:349–58.
Brindis RG, Douglas PS, Hendel RC, Peterson ED, Wolk MJ, Allen JM, et al. ACCF/ASNC appropriateness criteria for singlephoton emission computed tomography myocardial perfusion imaging (SPECT MPI): A report of the American College of Cardiology Foundation Quality Strategic Directions Committee Appropriateness Criteria Working Group and the American Society of Nuclear Cardiology endorsed by the American Heart Association. J Am Coll Cardiol 2005;46:1587–605.
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Venkataraman, R., Heo, J., Hendel, R.C. et al. The role of first-pass radionuclide angiography in the era of gated SPECT myocardial perfusion imaging. J Nucl Cardiol 15, 838–840 (2008). https://doi.org/10.1007/BF03007366
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DOI: https://doi.org/10.1007/BF03007366