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The adenosine triphosphate (ATP) depletion test: Comparison with the caffeine contracture test as a method of diagnosing malignant hyperthermia susceptibility

  • Published: November 1976
  • Volume 23, pages 624–635, (1976)
  • Cite this article
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Canadian Anaesthetists’ Society Journal Aims and scope Submit manuscript
The adenosine triphosphate (ATP) depletion test: Comparison with the caffeine contracture test as a method of diagnosing malignant hyperthermia susceptibility
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  • Beverley A. Britt1,
  • Laszlo Endrenyi1,2,
  • Werner Kalow1,2 &
  • …
  • Pearl L. Peters1,2 

  • 482 Accesses

  • 35 Citations

  • Explore all metrics

Summary

The adenosine triphosphate (ATP depletion ratio, which is the ratio [ATP] in skeletal muscle equilibrated with carbogen and 4% halothane for 30 minutes/

[ATP] in skeletal muscle equilibrated with carbogen alone for 30 minutes is less than normal in most but not in all rigid MHS patients. The ratio is normal in non-rigid MHS patients. This diagnostic tool is, therefore, useful in the diagnosis of rigid MH. It is not, however, such a sensitive diagnostic parameter as the caffeine contracture test.

Résumé

Le rapport de 1a déplétion en adénosine triphosphate, qui est le rapport entre : (ATP) dans le muscle squelettique mis en équilibre avec du carbogène et 4% d’Halothane durant 30 minutes/ (ATP) dans le muscle squelettique mis en équilibre avec du carbogène durant 30 minutes est plus petit que normalement chez la plupart des patients qui ont une susceptibilité à la forme rigide de l’hyperthermie maligne, mais non chez tous. Ce rapport est normal dans la forme non rigide. Il s’agit donc d’un examen utile dans le diagnostic de la forme rigide de l’hyperthermie maligne. Cet examen n’est toutefois pas aussi sensible que celui de la contraction musculaire à la caféine.

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Authors and Affiliations

  1. Departments of Anaesthesia and Pharmacology, University of Toronto, Toronto, Ontario

    Beverley A. Britt, Laszlo Endrenyi, Werner Kalow & Pearl L. Peters

  2. Department of Pharmacology, University of Toronto, Toronto, Ontario

    Laszlo Endrenyi, Werner Kalow & Pearl L. Peters

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  1. Beverley A. Britt
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Britt, B.A., Endrenyi, L., Kalow, W. et al. The adenosine triphosphate (ATP) depletion test: Comparison with the caffeine contracture test as a method of diagnosing malignant hyperthermia susceptibility. Canad. Anaesth. Soc. J. 23, 624–635 (1976). https://doi.org/10.1007/BF03006745

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  • Issue Date: November 1976

  • DOI: https://doi.org/10.1007/BF03006745

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Keywords

  • Caffeine
  • Halothane
  • Malignant Hyperthermia
  • Carbogen
  • Muscle Fascicle
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