Summary
Fazadinium at two dose levels (1 mg/kg and 1.5 mg/kg) and suxamethonium at three dose levels (50 mg, 75 mg and 100 mg) were investigated in 106 adult patients to determine the time interval from injection to tracheal intubation. The intubating conditions were graded according to the scheme described by Lund and Stovner. Suxamethonium 100 mg gave the shortest time interval between the end of injection and intubation. There was no significant difference between the intubation time when smaller doses of suxamethonium (50 mg and 75 mg) were used and those when AH8165 (1 mg and 1.5 mg/kg) were given. Suxamethonium 100 mg also produced a significantly higher incidence of excellent intubating conditions. The clinical implications of the findings are discussed.
Résumé Cette étude portait sur le suxamethonium et le fazadinium, un nouveau relaxant non dépolarisant, et avait pour but de comparer le délai séparant ľinjection et ľintubation. La qualité de relâchement obtenue a également été évaluée suivant le barème de Lund et Stovner.
Cent six patients adultes ont fait ľobjet de nos observations. Les doses utilisées étaient de 1 et de 1.5 mg/kilo pour le Fazadinium et de 50, 75 et 100 mg pour le suxamethonium.
Le suxamethonium, à la dose de 100 mg, a donné les plus cours délais entre la fin de ľinjection et ľintubation.
Les intervalles n’étaient pas significativement différents entre le fazadinium à 1.5 mg/kilo et le suzamethonium lorsqu’il était utilisé à des doses de 50 ou de 75 mg. p Une dose de 100 mg de suxamethonium produisait également et de façon significative un plus haut pourcentage de conditions excellentes pour ľintubation.
Les auteurs commentment les applications cliniques de leurs résultats.
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Mehta, S., Lewin, K. & Fidler, K. Rapid intubation with fazadinium and suxamethonium. Canad. Anaesth. Soc. J. 24, 270–274 (1977). https://doi.org/10.1007/BF03006240
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DOI: https://doi.org/10.1007/BF03006240