Summary
Ketamine and pancuronium have been administered intravenously either in rapid sequence or mixed together for the induction of anaesthesia. The subjects were either healthy patients or those suffering from coronary artery disease or mitral stenosis. Changes in blood pressure and pulse rate were variable, a marked tachycardia occurring in some patients. The opinion is expressed that this combination of drugs is potentially dangerous for some patients. Only a careful assessment of each patient in the light of the cardiovascular problem and such other drugs as have been or will be administered, can enable a rational decision to be made regarding the use of this technique for the induction of anaesthesia.
RéSUMé
Chez deux groupes de malades, les uns en bonne santé, les autres souffrant d’insuffisance coronarienne ou de sténose mitrale, nous avons effectué l’induction de l’anesthésie avec de la Kétamine et du Pancuronium intra-veineux, soit en solution pré-mélangée ou en injections séquentielles rapides.
Les changements du pouls et de la pression artérielle furent variables avec occasionnellement une tachycardie marquée chez certains malades. Nous sommes d’opinion que cette association médicamenteuse est potentiellement dangereuse dans certains cas. C’est seulement à la suite d’une évaluation attentive de chaque malade, de son état cardio-vasculaire et des médicaments qu’il a reçus ou recevra, qu’on décidera d’une façon éclairée de l’indication d’une telle méthode d’induction.
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References
Stanley, V., Hunt, J., Willis, K.N., &Stephen, C.R. Cardiovascular and respiratory function with CI-581. Anesth. & Analg.47: 760 (1968).
Coppel, C.L. &Dundee, J.W. Ketamine anaesthesia for cardiac catheterization. Anaesthesia27: 25 (1972).
Bovill, J.G. &Dundee, J.W. Attempts to control the cardio stimulatory effect of ketamine. Anaesthesia27: 309 (1972).
Tweed, W.A., Minuck, M., &Mymin, D. Circulatory responses to ketamine anesthesia. Anesthesiology37: 613 (1972).
Savece, T.M., Blogg, C.E., Foley, E.J., Ross, L., Lang, M., &Simpson, B.R. The cardiorespiratory effects of Althesin and Ketamins. Anaesthesia28: 391 (1973).
Traber, D.L., Wilson, R.D., &Priano, L.L. The effect of alpha-adrenergic blockade on the cardiopulmonary response to ketamine. Anesth. & Analg.50: 737 (1971).
Chodoff, P. Evidence for central adrenergic action of ketamine. Anesth. & Analg.51: 247(1972).
Lobke, P. &Dannmann, H.J. Uber den einfluz von pancuronium bromide auf das herz Kreislaufverhalten in Neuroleptanalgesie. Anesthetist20: 402 (1971).
Kelman, G.R. &Kennedy, B.R. Cardiovascular effects of pancuronium in man. Brit. J. Anaesth.43:335(1971).
Gertel, M., Fox, G.S., Rabow, F., &Graham, D.H. The cardiovascular effects of pancuronium bromide during halothane anaesthesia. Can. Anaesth. Soc. J.19: 599 (1972).
Coleman, A.J., Downing, J.W., Leahy, W.P., Moves, D.G., &Styles, M. The immediate cardiovascular effects of pancuronium, alcuronium and tubocurarine in man. Anaesthesia27:415(1972).
Stoeltinc, R.K. The hemodynamic effects of pancuronium and d-tubocurarine in anaesthetized patients. Anesthesiology36: 612 (1972).
Saxena, P.R. &Bonta, I.L. Specific blockade of cardiac muscarinic receptors by pancuronium bromide. Arch Int. Pharmaco. Therap.189: 410 (1971).
McIntyre, J.W.R. &Gain, E.A. Initial experience during the clinical use of pancuronium bromide. Anesth. & Analg.50: 813 (1971).
Sanchez, R., Canseco, J.L.T., Acuna, L., &Mireles, M. The use of ketamine on patients undergoing cardiac surgery. Anesthetist20: 152 (1971).
Corssen, G. Ketamine for high risk cardiac patients. Anesthesiology36: 413 (1972).
Dillon, J.B. Ketamine. Proc. Roy. Soc. Med.64:1153 (1971).
Lorhan, P.H. &Lippmann, M. Clinical appraisal of pancuronium bromide for the aged patient. Anesth. & Analg.51: 914 (1972).
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McIntyre, J.W.R., Dobson, D. & Aitken, G. Ketamine with pancuronium for induction of anaesthesia. Canad. Anaesth. Soc. J. 21, 475–481 (1974). https://doi.org/10.1007/BF03005842
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DOI: https://doi.org/10.1007/BF03005842