Abstract
Lidocaine can be prepared in a variety of ways which may affect the characteristics of neural blockade achieved. Experimental evidence is equivocal as to the clinical impact of the use of different lidocaine preparations. A randomized, double-blind study was performed to investigate the differences in epidural anaesthesia for Caesarean section using three different lidocaine solutions: lidocaine CO2, two per cent lidocaine and two per cent lidocaine with its pH adjusted by the addition of bicarbonate. No differences were found among the groups in time of onset of neural blockade, quality or duration of neural blockade, time to delivery of the infant or volume of anaesthetic solution injected into the epidural space. A significant difference was found between the pH’s of the solutions used. It is concluded that all three solutions are equally efficacious in epidural anaesthesia for Caesarean section.
Résumé
Théoriquement, on peut moduler un bloc nerveux en choisissant parmi les diverses preparations de lidocaïne disponibles. On ne sait toutefois pas si ces différences ont un impact pratique. Dans le cadre d’une étude randomisée et à double insu lors de césariennes, nous avons évalué les caractéristiques du bloc nerveux produit par la lidocaïne CO2, la lidocaïne à deux pour cent et la lidocaïne à deux pour cent avec pH ajusté par addition de bicarbonate. Le temps de latence, la durée et la qualité du bloc, le volume d’ anesthésique injecté et le temps s’écoulant jusqu’à la naissance étaient semblables d’un groupe à l’autre. Les solutions avaient cependant un pH significativement différent. Toutes ces préparations sont également efficaces pour obtenir une anesthésie épidurale appropriée à une césarienne.
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Liepert, D.J., Douglas, M.J., McMorland, G.H. et al. Comparison of lidocaine CO2, two per cent lidocaine hydrochloride and pH adjusted lidoaine hydrochloride for caesarean section anaesthesia. Can J Anaesth 37, 333–336 (1990). https://doi.org/10.1007/BF03005585
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DOI: https://doi.org/10.1007/BF03005585