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Comparison of endocrinological stress response associated with transvaginal ultrasound-guided oocyte pick-up under halothane anaesthesia and neuroleptanaesthesia

Canadian Journal of Anaesthesia volume 36, pages 633–636 (1989)Cite this article

Abstract

Twelve patients with mechanical infertility in the in vitrofertilization program were studied. Seven of them received halothane anaesthesia and the other five received neuroleptanaesthesia. Higher plasma prolactin levels and lower plasma progesterone levels were observed in the neuroleptanaesthesia group than in the halothane group during and after transvaginal ultrasound-guided oocyte pick-up. Plasma adrenocorticotropic hormone and cortisol levels of the patients suggested that surgical stress was minimal in both groups. It is likely that droperidol and fentanyl, both used in neuroleptanaesthesia, were responsible for the hyperprolactinaemia which was followed by inhibition of progesterone production. These agents, therefore, are not recommended as anaesthetic agents for transvaginal ultrasound-guided oocyte pick-up.

Résumé

Dans le cadre d’un programme de fertilisation in vitro, on a fait la cueillette d’ovules par voie transvaginale avec échographie chez 12 femmes infertiles. Pour ce faire, nous en avons anesthé siées sept avec de l’halothane et cinq par neuroleptanesthésie. En mesurant les niveaux plasmatiques pendant et après la procédure, nous avons trouvé plus de prolactine et moins de progestérone avec l’halothane qu’avec la neuroleptanesthésie. Les quantités d’ACTH et de cortisol plasmatiques, faibles dans les deux groupes, suggèrent un niveau minimal de stress chirurgical. II est probable que le dropéridol et le fentanyl, utilisés dans le groupe neuroleptanesthésie, soient responsables d’une hyperprolactinémie suivie d’une inhibition de la sécrétion de progestérone et de ce fait, ils devraient être évités lors de la cueillette d’ovules.

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Affiliations

  1. Department of Anesthesia, Kyoto University School of Medicine, Sakyo-ku, 606, Kyoto, Japan

    Yoshiyuki Naito, Sunao Tamai, Norimasa Seo & Kenjiro Mori

  2. Second Division, Department of Medicine, Kyoto University School of Medicine, Sakyo-ku, 606, Kyoto, Japan

    Junichi Fukata, Yoshikatsu Nakai & Hiroo Imura

Authors
  1. Yoshiyuki Naito
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  2. Sunao Tamai
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  3. Junichi Fukata
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  4. Norimasa Seo
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  5. Yoshikatsu Nakai
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  6. Hiroo Imura
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  7. Kenjiro Mori
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Additional information

The present study was supported in part by the Yanase Memorial Foundation, and by the Fujiwara Memorial Foundation.

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Naito, Y., Tamai, S., Fukata, J. et al. Comparison of endocrinological stress response associated with transvaginal ultrasound-guided oocyte pick-up under halothane anaesthesia and neuroleptanaesthesia. Can J Anaesth 36, 633–636 (1989). https://doi.org/10.1007/BF03005413

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  • DOI: https://doi.org/10.1007/BF03005413

Key words

  • Anaesthesia: gynaecological
  • Anaesthetics, Intravenous: droperidol, fentanyl
  • Anaesthetics, Volatile:halothane
  • Hormones: adrenocorticotropic, corti-costeroid, luteinizing, progesterone, prolactin