Serum free fatty acid and blood sugar levels in children under halothane, thiopentone and ketamine anaesthesia (comparative study)

An Erratum to this article was published on 01 September 1975

Summary

Serum free fatty acid and blood glucose levels were determined in 30 children under halothane, thiopentone and ketamine anaesthesia. Blood sugar is increased above baseline values by halothane 54.75 per cent (+++), thiopentone 71.7 per cent (++++) and ketamine 12.2 per cent (+) anaesthesia. Serum free fatty acid was increased during halothane 58.7 per cent (+++) and thiopentone 34.4 per cent (++) anaesthesia, but was decreased with ketamine anaesthesia 13.4 percent (-).

It is assumed that several factors contribute to these changes and are related either to the sympathetic nervous system or basal metabolism and to the specific actions of each drug.

RéSUMé

Chez 30 enfants anesthésiés à l’halothane, au thiopentone et à la kétamine, on a mesuré le taux d’acide gras circulant et la glycémie. Ces trois agents augmentent la glycémie à des degrés divers: halothane 54.75 pour cent, thiopentone 71.7 pour cent et kétamine 12.2 pour cent. Le taux d’acide gras circulant augmente durant l’anesthésie à l’halothane (58.7 pour cent) et au thiopentone (34.4 pour cent) mais diminue durant l’anesthésie à la kétamine (-13.4 pour cent).

Plusieurs facteurs contribuent à ces changements qui sont attribuables ou bien l’activité du système nerveux sympathique sur le métabolisme basai ou à l’action spécifique de chaque agent.

References

  1. 1.

    Dobkin, A.B. &Fedoruk, S.A. A comparison of the cardiovascular, respiratory and metabolic effects of methoxyflurane and halothane in dogs. Anesthesiology22: 355 (1961).

    PubMed  CAS  Article  Google Scholar 

  2. 2.

    Gervenko, F.W. &Grene, N.M. Effect of cyclopropane anesthesia on glucose assimilation coefficient in man. Anesthesiology28: 914 (1967).

    Article  Google Scholar 

  3. 3.

    Galla, S.I. Glucose pool size, turnover rate and CO2 production during halothane anesthesia in dogs. Anesthesiology28: 251 (1967).

    Article  Google Scholar 

  4. 4.

    Galla, S.J. &Wilson, E.F. Hexose metabolism during halothane anesthesia in dogs. Anesthesiology25: 96 (1964).

    Article  Google Scholar 

  5. 5.

    Keating, V.,et al. Halothane and carbohydrate metabolism. Anesthesia14: 268 (1969).

    Article  Google Scholar 

  6. 6.

    Martinez, C. Effect of barbituric acid on alloxan diabetes in rats and dogs. Am. J. Physiology182: 267 (1955).

    CAS  Google Scholar 

  7. 7.

    Hensel, I.,et al. Untersuchungen über Kreislauf- und Stoffwechselveränderungen unter Ketamine Narcose. Der Anaesthesist21: 44 (1972).

    PubMed  CAS  Google Scholar 

  8. 8.

    Duncomb, W.G. Colorometric method of determination of plasma nonesterified fatty acids. Clinical Ch. Act.9: 122 (1964).

    Article  Google Scholar 

  9. 9.

    Howorth, P.J.N.,et al. Evaluation of a colorometric method of determination of plasma nonesterified fatty acids. Clinical chem. Act.14: 69 (1966).

    Article  CAS  Google Scholar 

  10. 10.

    Werner, W., Rey, H.G., &Wielinger, H. Properties of a new chromogen for the determination of glucose in blood according to the GOD/POD (Glucose oxidase-peroxidase) method. Fresenicus Z. Anal. Chem. 1970. 252 (2-3) 224–8 (Germ.).

    Article  CAS  Google Scholar 

  11. 11.

    Hunter, A.R. Halothane and blood sugar. Anesthesiology31: 490 (1959).

    CAS  Google Scholar 

  12. 12.

    Kaniaris,et al. Relation between glucose tolerance and serum insulin levels in humans before and after thiopental I.V. injection in humans. Acta Anesthesiologyca Hellenica6: 163 (1973).

    Google Scholar 

  13. 13.

    Borgman, R.L.,et al. Effects of barbiturates on skeletal muscle function. Anesthesiology21: 150 (1960).

    PubMed  Article  CAS  Google Scholar 

  14. 14.

    Bortels, E.C. Basal metabolism testing under pentothal anesthesia. J. Clin. Endocrinology9: 1190 (1949).

    Article  Google Scholar 

  15. 15.

    Brody, J.M. &Bain, S.A. Effect of barbiturates on oxidative Phosphorylation. Proc. Soc. exp. biol. Medicine77: 50 (1957).

    Google Scholar 

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Correspondence to P. Kaniaris or D. Lekakis or M. Kykoniatis or E. Kastanas.

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An erratum to this article is available at http://dx.doi.org/10.1007/BF03013418.

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Kaniaris, P., Lekakis, D., Kykoniatis, M. et al. Serum free fatty acid and blood sugar levels in children under halothane, thiopentone and ketamine anaesthesia (comparative study). Canad. Anaesth. Soc. J. 22, 509–518 (1975). https://doi.org/10.1007/BF03004867

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Keywords

  • Ketamine
  • Halothane
  • Thiopentone
  • CANADIAN Anaesthetist
  • Blood Sugar Level