Serum free fatty acid and blood sugar levels in children under halothane, thiopentone and ketamine anaesthesia (comparative study)

An Erratum to this article was published on 01 September 1975


Serum free fatty acid and blood glucose levels were determined in 30 children under halothane, thiopentone and ketamine anaesthesia. Blood sugar is increased above baseline values by halothane 54.75 per cent (+++), thiopentone 71.7 per cent (++++) and ketamine 12.2 per cent (+) anaesthesia. Serum free fatty acid was increased during halothane 58.7 per cent (+++) and thiopentone 34.4 per cent (++) anaesthesia, but was decreased with ketamine anaesthesia 13.4 percent (-).

It is assumed that several factors contribute to these changes and are related either to the sympathetic nervous system or basal metabolism and to the specific actions of each drug.


Chez 30 enfants anesthésiés à l’halothane, au thiopentone et à la kétamine, on a mesuré le taux d’acide gras circulant et la glycémie. Ces trois agents augmentent la glycémie à des degrés divers: halothane 54.75 pour cent, thiopentone 71.7 pour cent et kétamine 12.2 pour cent. Le taux d’acide gras circulant augmente durant l’anesthésie à l’halothane (58.7 pour cent) et au thiopentone (34.4 pour cent) mais diminue durant l’anesthésie à la kétamine (-13.4 pour cent).

Plusieurs facteurs contribuent à ces changements qui sont attribuables ou bien l’activité du système nerveux sympathique sur le métabolisme basai ou à l’action spécifique de chaque agent.


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Correspondence to P. Kaniaris or D. Lekakis or M. Kykoniatis or E. Kastanas.

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Kaniaris, P., Lekakis, D., Kykoniatis, M. et al. Serum free fatty acid and blood sugar levels in children under halothane, thiopentone and ketamine anaesthesia (comparative study). Canad. Anaesth. Soc. J. 22, 509–518 (1975).

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  • Ketamine
  • Halothane
  • Thiopentone
  • CANADIAN Anaesthetist
  • Blood Sugar Level