Summary
The respiratory response to hypercapnia in dogs anaesthetized with ketamine was increased. This respiratory stimulation was most probably due to a direct effect of the drug on the medullary respiratory neurones. This effect was not modified by preanaesthetic medication pentobarbitone 5 mg/kg or morphine 0.1 mg/kg.
Catecholamine response to hypercapnia was essentially the same as that reported by hypercapnic dogs anaesthetized with thiopentone.
Résumé
La réponse ventilatoire à l’hypercapnie provoquée chez des chiens anesthésiés à la kétamine est augmentée. Cette stimulation respiratoire est, selon toute probabilité attribuable à l’effet direct du médicament, sur les centres respiratoires médullaires. Une prémédication au pentobarbitone (5 mg/kg) ou à la morphine (0.1 mg/kg) n’a pas modifié cette réaction.
Le taux de catécholamines lié à l’hypercapnie est essentiellement le même chez les chiens anesthésiés à la kétamine ou au thiopentone.
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This study was supported by grant NA-4602 from the Medical Research Council of Canada.
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Soliman, M.G., Brindle, G.F. & Kuster, G. Response to hypercapnia under ketamine anaesthesia. Canad. Anaesth. Soc. J. 22, 486–494 (1975). https://doi.org/10.1007/BF03004864
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DOI: https://doi.org/10.1007/BF03004864