Summary
We have compared cardiac output, gas exchange and pulmonary mechanics during spontaneous breathing and artificial ventilation under conditions which kept PaCO 2 within the normal range and maintained constant tidal volume and inspired gas flow rate.
In dogs anaesthetized with pentobarbitone and ventilated with air, artificial ventilation increased VD/VT but did not reduce\(\dot Q\), FRC, or CL. PaO 2 increased and A-aDo 2 decreased during artificial ventilation, perhaps because of a small increase in\(\dot Q\) and a small decrease in oxygen consumption. It appears that many of the reported deleterious effects of artificial ventilation may be due to the use of other anaesthetic agents and patterns of ventilation, and to changes in PaCO 2.
Résumé
Nous avons comparé le débit cardiaque, les échanges gazeux et la dynamique pulmonaire lors de respiration spontanée et de ventilation contrôlée dans des conditions qui nous permettaient de garder une PaCO 2 dans les limites normales et de ventiler avec des volumes courants et un débit de gaz inspirés constants.
Chez des chiens anesthésiés avec du pentobarbital et ventilés avec de l’air, la ventilation artificielle a augmenté vd/vt, mais n’a pas diminué\(\dot Q\), FRC, ou CL. L’augmentation de PaO 2 et la diminution de A-aDO 2, pourraient être dues à l’augmentation légère du\(\dot Q\) et à une diminution légère de la consommation d’O2. Il semble que plusieurs des effets nocifs rapportés concernant la ventilation artificielle seraient dûs à l’emploi de d’autres agents anesthésiques et d’autres types de ventilation, et à des changements de PaCO 2.
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Supported in part by a grant from the Canadian Medical Research Council. Some of the equipment used in this study was purchased with funds from the Red Cross Youth, Ontario.
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Arthur, D.S., Mathur, A.K., Nisbet, H.I.A. et al. The effect of artificial ventilation on functional residual capacity and arterial oxygenation. Canad. Anaesth. Soc. J. 22, 432–435 (1975). https://doi.org/10.1007/BF03004857
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DOI: https://doi.org/10.1007/BF03004857