Summary
The central nervous system and concurrent cardiovascular effects of bupivacaine infusion were studied in cats. It was possible to block cortical E.E.G. desyn-chronization resulting from a sensory stimulus with bupivacaine. The earliest subcortical change that occurred was rhythmic activity in the amygdala and later in the hippocampus. Occasionally, this activity appeared simultaneously in both these sites. Diazepam pretreatment raised the seizure threshold of bupivacaine. Diazepam was also effective in terminating established seizure activity resulting from bupivacaine. All animals pretreated with diazepam (Valium®) or diazepam solvent developed cardiac dysrhythmias during bupivacaine infusion. The possible clinical significance of the interaction of bupivacaine and diazepam solvent is considered.
Résumé
Nous avons étudié les effets d’une perfusion de Bupivacaine sur les systèmes nerveux et cardio-vasculaire du chat.
La Bupivacaine est capable de prévenir sur l’électro-encéphalogramme cortical, l’apparition de la désynchronisation qui suit normalement une stimulation sensorielle.
Au niveau sous-cortical, les changements les plus précoces, (activités rythmiques), se manifestent d’abord à l’amygdale, ensuite à l’hippocampe, quelques fois aux 2 endroits en même temps. Le Diazepam administré préventivement élève le seuil commitial de Bupivacaïne et est aussi capable d’inhiber les manifestations convulsives induites par celle-ci.
Tous les animaux prétraités au Diazepam ou à son solvant, ont présenté des arythmies durant la perfusion de Bupivacaïne.
La signification clinique de cette interaction médicamenteuse est discutée dans l’article.
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Robinson, W.M., Jenkins, L.C. Central nervous system effects of bupivacaine. Canad. Anaesth. Soc. J. 22, 358–369 (1975). https://doi.org/10.1007/BF03004845
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DOI: https://doi.org/10.1007/BF03004845