Summary
Eight pregnant Sprague-Dawley rates were exposed to 10 ppm halothane 8 hours/day and 5 days/week throughout pregnancy. Liver samples were obtained from the pups for electron microscopy. Degenerative changes such as myelin-figure formation, focal-cytoplasmic degradation; fatty changes and cellular necrosis were observed. Leukocytic infiltration and phagocytosis of the cellular debris by Kupffer cells were also evident. The present investigation has demonstrated the hepatotoxic effects of halothane on the foetal liver. The role of halothane as an occupational hazard is considered.
Résumé
Huit rates enceintes, type Sprague-Dawley, ont été exposées à 10 ppm d’halothane à raison de huit heures par jour et cinq jours par semaine pendant toute leur grossesse. Des échantillons de foie foetal ont été prélevées et examinées à la microscopie électronique.
Les changements dégénératifs suivants ont été notés: formation “myéline-like” dégradation cytoplasmique focale, nécrose cellulaire et dégénérescence graisseuse. Les cellules de Kupffer sont remplies de débris cellulaires et une infiltration leucocytaire diffuse a été remarquée également. Donc, cette étude montre bien les effets hépato-toxiques de l’halothane sur le foie foetal. On peut extrapoler cela en pensant au personnel de la salle d’opération (anesthésistes, infirmières, chirurgiens), qui est exposé à des concentrations semblables, durant de longues périodes de temps.
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Chang, L.W., Lee, Y.K., Dudley, A.W. et al. Ultrastructural evidence of the hepatotoxic effect of halothane in rats following in-utero exposure. Canad. Anaesth. Soc. J. 22, 330–338 (1975). https://doi.org/10.1007/BF03004842
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DOI: https://doi.org/10.1007/BF03004842