Summary
THE frequency of methicillin resistant Staphylococcus aureus isolated from pathological material from eight Dublin hospitals between April, 1971 and April, 1972 was 5.4 per cent. This frequency justifies their routine detection.
Characteristics of 90 methicillin resistant strains are examined. They include antibiotic sensitivity and sensitivity to metal ions, phage types, lipolytic activity, heterogeneity and temperature studies.
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References
Al Salihy, S. M. and James, A. M. 1972. Loss of methicillin-resistance from resistant strains of Staphylococcus aureus. Lancet ii, 331.
Annear, D. I. 1968. The effect of temperature on resistance of Staphylococcus aureus to methicillin and some other antibiotics. Med. J. Aust. 1, 444.
Barber, Mary, Dutton, A. A. C., Beard, M. A., Elmes, P. C. and Williams, R. 1960. Reversal of antibiotic resistance in hospital staphylococcal infection. Br. med. J. i, 11.
Marber, Mary 1964. Naturally occurring methicillin resistant staphylococci. J. Gen. Microbiol. 35, 183.
Barrett, F. F., McGehee, R. F. and Finland, M. 1968. Methicillin resistant Staphylococcus aureus at Boston City Hospital. New Engl. J. Med. 279, 441.
Benner, E. J. and Kayser, F. H. 1968. Clinical significance of methicillin resistant Staphylococcus aureus. Lancet, ii, 741.
Blair, J. E. and Williams, R. E. O. 1961. Phage typing of staphylococci. Bull. Wld. Hlth. Org. 24, 771.
Chabbert, Y. A., Budens, J. G., Acar, T. F. and Gerbaud, G. R. 1965. La resistance naturelle des Staphylocoques a La Methicillins et l'Oxacillins. Revue fr. Etud. Clin. Biol. 10, 495.
Churcher, Gillian M. 1968. A screening test for the detection of methicillin resistant staphylococci. J. Clin. Path. 21, 213.
Cohen, S. and Sweeney, H. M. 1970. Transduction of methicillin resistance in Staphylococcus aureus dependent on an unusual specificity of the recipient strain. J. Bacteriol. 104, 1158.
Cowan, S. T. and Steel, K. J. 1970. Identification of Medical Bacteria. Cambridge University Press. pp. 153–154.
Darrell, J. H., Garrod, L. P. and Waterworth, Pamela M. 1968. Trimethoprim: laboratory and clinical studies. J. Clin. Path. 21, 202.
Dornbush, K., Hallender, H. O. and Lofquist, F. 1969. Extra-chromosomal control of methicillin resistance and toxin production in Staphylococcus aureus. J. Bacteriol. 98, 351.
Dyke, K. G. H., Parker, M. T. and Richmond, M. H. 1970. Penicillinase production and metal ion resistance in Staphylococcus aureus cultures isolated from hospital patients. J. Med. Microbiol. 3, 125.
Garrod, L. P. and Waterworth, Pamela M. 1971. A study of antibiotic sensitivity testing with proposals for simple uniform methods. J. Clin. Path. 24, 779.
Goldie, D. J., Alder, V. G. and Gillespie, W. A. 1971. Changes in the drug resistance of Staphylococcus aureus in a non hospital population during a 20-year period. J. Clin. Path. 24, 44.
Green, Susan M. 1962. Mercury sensitivity of staphylococci. J. Clin. Path. 15, 249.
Grubb, W. B. and Annear, D. I. 1972. Spontaneous loss of methicillin resistance in Staphylococcus aureus at room temperature. Lancet ii, 1257.
Hewitt, J. H., Coe, A. W. and Parker, M. T. 1969. The detection of methicillin resistance in Staphylococcus aureus. J. Med. Microbiol. 2, 443.
Jevons, M. Patricia. 1961. Celbenin-resistant staphylococci. Br. med. J. i, 124.
Jessen, Q. Faber, V., Rosendal, K. and Ericsen, K. R. 1959. Some properties of Staphylococcus aureus possibly related to pathogenicity. Acta. Path. Microbiol. Scand. 47, 316.
Jessen, O., Rosendal, K., Bulow, P., Faber, V. and Ericksen, M. R. 1969. Changing Staphylococci and Staphylococcal infections. New Engl. J. Med. 281, 627.
May, J. R. and Davies, J. 1972. Resistance of haemophilus influenzae to trimethoprim. Br. med. J. 3, 376.
Moorhouse, Ellen C. and Farrell, Wendy. 1971. Nasal and intestinal carriage of antibiotic resistant bacteria by patients on admission to hospital. J. Irish. Med. Ass. 64, 571.
Nakhia, L. S. 1972. Resistance of Staphylococcus aureus to sulphamethoxazole and trimethoprim. J. Clin. Path. 25, 708.
Parker, M. T. and Hewitt, J. H. 1970. Methicillin resistance in Staphylococcus aureus. Lancet i, 800.
Siboni, K., Poulsen, L. and Digman, E. 1968. The dominance of methicillin resistant staphylococci in a county hospital. Danish Medical Bulletin. 15, 161.
Sierra, G. 1957. A simple method for the detection of lipolytic activity of micro-organisms and some observations on the influence of the contact between cells and fatty substrates. Antonie Leeuwenhoek, J. Microbiol. Serol. 23, 15.
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Hone, R., Keane, C.T. Characteristics of methicillin resistant Staphylococcus aureus. Ir J Med Sci 143, 145–154 (1974). https://doi.org/10.1007/BF03004756
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DOI: https://doi.org/10.1007/BF03004756