References
Anderson, B., Belcher, E. H., Chanarin, I. and Mollin, D. L. 1960. The urinary and faecal excretion of radio-activity after oral doses of3H folic acid. Brit. J. Haemat., 6, 439.
Badenoch, J. 1960. Steatorrhoea in the adult. Brit. med. J., i, 879.
Baird, I. McL., Podmore, D. A. and Wilson, G. M. 1957. Changes in iron metabolism following gastrectomy and other surgcial operations. Clin. Sci., 16, 463.
Baird, I. McL. and Wilson, G. M. 1959. The pathogenesis of anaemia after partial gastrectomy. II. Iron absorption after partial gastrectomy. Quart. J. Med., 28, 35.
Baker, H., Frank, O., Feingold, S., Ziffer, H., Gellene, R. A., Leevy, C. M. and Sobotka, H. 1965. The fate of orally and parenterally administered folates. Amer. J. clin. Nutr., 17, 88.
Baker, H., Thompson, A. D., Feingold, S. and Frank, O. 1969. Role of the jejunum in the absorption of folic acid and its polyglutamates. Amer. J. clin. Nutr., 22, 124.
Baker, S. and Mathan, V. I. 1970. Tropical sprue in Southern India. In ‘Tropical Sprue’. The Wellcome Trust. Churchill and Sons. London.
Baugh, C. M. and Krumdieck, C. L. 1969. Effects of phenytoin on folic acid enzymes in man. Lancet, ii, 9.
Baugh, C. M., Krumdieck, C. L., Baker, H. J. and Butterworth, C. E. 1971. Studies on the absorption and metabolism of folic acid. 1. Folate absorption in the dog after exposure of isolated intestinal segments to synthetic pteroylpolyglutamates of various chain lengths. J. clin. Invest., 50, 2009.
Benn, A., Swann, C. H. J., Cooke, W. T., Blair, J. A., Matty, A. J. and Smith, M. E. Effect of intraluminal pH on the absorption of pteroylmonoglutamic acid. Brit. med J., i. 148.
Bernstein, L. H., Gutstein, S., Weiner, S. and Efron, G. 1970. The absorption and malaborption of folic acid and its polyglutamates. Amer. J. Med., 48, 570.
Blake, J. and Rechnitzer, P. A. 1953. The haematological and nutritional effects of gastric operations. Quart. J. Med., 22, 419.
Brown, J. P., Scott, J. M., Foster, F. G. and Weir, D. G. 1973a. Ingestion and absorption of naturally occurring pteroylmonoglutamates (folate) in man. Gastroenterology, 64, 223.
Brown, J. P., Davidson, G. E., Weir, D. G. and Scott, J. M. 1973b. Effect of diphenylhydantoin and ethanol feeding on the synthesis of rat liver folates from exogenous pteroylglutamate (3H). Biochem. Pharmac. (In press).
Butterworth, C. E., Baugh, C. M. and Krumdieck, C. 1969. A study of folate absorption and metabolism in man utilising carbon-14 labelled polyglutamates synthesised by the solid phase method. J. clin. Invest., 48, 1, 131.
Butterworth, C. E., Santini, R. Jr., and Frommeyer, W. B. 1963. The pteroylglutamate components of American diets as determined by chromatographic fractionation. J. clin. Invest., 42, 1, 929.
Carey, M. C., Fennelly, J. J. and Fitzgerald, O. 1968. Homocystinuria. 11. Subnormal serum folate levels, increased folate clearance and effects of folic acid therapy. Amer. J. Med., 45, 26.
Chanarin, I. C. 1969. The Megaloblastic Anaemias. Blackwell Scientific Publications, Oxford and Edinburgh.
Chanarin, I. MacGibbon, B. B., O'Sullivan, W. J. and Mollin, D. L. 1959. Folic acid deficiency in pregnancy. The pathogenesis of megaloblastic anaemia of pregnancy. Lancet, ii, 634.
Cherrick, G. R., Baker, H., Frank, O. and Leevy, C. M. 1965. Obersvations on hepatic avidity for folate in Laennec's cirrhosis. J. lab. clin. Med., 66, 446.
Corrocher, R., Bhuyan, B. K. and Hoffbrand, A. V. 1972. Composition of pteroylpolyglutamates (conjugated folates) in guinea pig liver and their formation from folic acid. Clin. Sci., 43, 799.
Cox, E. V., Meynell, M. J., Cooke, W. T. and Gaddie, R. 1956. Folic acid excretion test in the steatorrhoea syndrome. Gastroenterology, 35, 390.
Croft, D. N., Loehry, C. A. and Creamer, B. 1968. Small bowel cell loss and weight loss in the coeliac syndrome. Lancet, ii, 18.
Davidson, G. E., Brown, J. P. and Scott, J. M. 1973. Pteroylpoly-λ-L-glutamates in the liver and kidney of the monkey (cyanmolgus sp.). Biochem. Soc. Trans. 1, in press.
Davidson, G. E., Brown, J. P., Houlihan, C. M. and Scott, J. M. 1974. Biosynthesis of folate compounds (Pteroylpoly-α-L-glutamates) in rat liver: Effect of vitamin B12 deficiency (unpublished).
Deller, D. J. and Witts, L. J. 1962. Changes in the blood after partial gastrectomy with special reference to vitamin B31. 1. Serum vitamin B12, haemoglobin, serum iron and bone marrow. Quart J. Med., 31, 71.
Dyer, N. H., Child, J. A., Mollin, D. L. and Dawson, A. M. 1972. Anaemia in Crohn's Disease. Quart J. Med., 41, 419.
Eichner, E. R., Buchanan, B., Smith, J. W. and Hillman, R. S. 1972. Variations in the haematologic and medical status of alcoholics. Amer. J. Med. Sci., 263, 35.
Eichner, E. R. 1973. The haematologica disorders of alcoholism. Amer. J. Med., 54, 621.
Elliott, R., Brown, J. and Weir, D. G. 1974. Unpublished observations.
Fehling, C., Jagerstad, M., Lindstrand, K. and Westesson, A. K. 1973. The effect of anticonvulsant therapy upon the absorption of folates. Clin. Sci., 44, 595.
Freedman, D. S., Brown, J. P., Weir, D. G. and Scott, J. M. 1973. The reproducibility and use of tritiated folic acid urinary excretion test as a measure of folate absorption in clinical practice. Effect of methotrexate on absorption of folic acid. J. clin. Path., 26, 261.
Freedman, D. S., Scott, J. M., Brown, J. P. and Weir, D. G. 1974. Effect of food and drugs on folate absorption. To be published.
Freedman, D. S., Scott, J. M., Brown, J. P. and Weir, D. G. 1974. Effect of intestinal resection on folate absorption. To be published.
Gatenby, P. B. B. 1956. Diet and anaemia. The anaemias of pregnancy in Dublin. Proc. Nutr. Soc., 15, 115.
Gatenby, P. B. B. 1960. Anticonvulsants as a factor in megaloblastic anaemia in pregnancy. Lancet, ii, 1004.
Gerson, C. D., Hepner, C. W., Brown, N., Cohen, H., Herbert, V. and Janowitz, H. D. 1972. Inhibition by diphenylhydantoin of folic acid absorption in man. Gastroenterology, 63, 246.
Gough, K. R., Read, A. E., McCarthy, C. F. and Waters, A. H. 1963. Megaloblastic anaemia due to nutritional deficiency of folic acid. Quart. J. Med., 32, 243.
Gough, K. R., McCarthy, C. F., Read, A. E., Mollin, D. L. and Waters, A. H. 1964. Folic acid deficiency in rheumatoid arthritis. Brit. med. J., i, 212.
Graves, R. 1864. Graves' clinical lectures on the Practice of Medicine. Edited by Neligan, Fannin & Co., Dublin.
Halsted, C. H., Robles, E. A. and Mezey, E. 1971. Decreased jejunal uptake of labelled folic acid (3H-PGA) in alcoholic patients: Roles of alcohol and nutrition. New. Eng. J. Med., 285, 701.
Hawkins, C. F. 1971. The investigation of malabsorption. J. clin. Path., 24, Suppl., 5, 151.
Henderson, J. G., Stachan, R. W., Beck, J. S., Dawson, A. P. and Daniel, M. 1966. The antigastric-antibody test as a screening procedure for vitamin B12 deficiency in psychiatric practice. Lancet, ii, 809.
Hepner, G. W. 1969. Absorption of folic acid in rats. Brit. J. Haemat., 16, 241.
Herbert, V., 1962. Experimental nutritional folate deficiency in man. Trans. Ass. Amer. Phycns., 75, 307.
Hines, J. D., Hoffbrand, A. V. and Mollin, D. L. 1967. The haematologic complications following partial gastrectomy. A study of 292 patients. Amer. J. Med., 43, 555.
Hines, J. D. 1969. Reversible megaloblastic and sideroblastic marrow abnormalities in alcoholic patients. Brit. J. Haemat., 16, 87.
Hines, J. D. and Cowan, D. H. 1970. Studies on the pathogenesis of alcohol induced sideroblastic bone marrow abnormalities. New. Eng. J. Med., 283, 441.
Hoffbrand, A. V., Hobbs, J. R., Kremenchuzky, S. and Mollin, D. L. 1967. Incidence and pathogenesis of megaloblastic erythropoiesis in multiple myeloma. J. clin. Path., 20, 699.
Hoffbrand, A. V., Chanarin, I., Kremenchuzky, S., Szur, L., Waters, A. H. and Mollin D. L. 1968. Megaloblastic erythropoiesis in myelosclerosis. Quart. J. Med., 37, 493.
Hoffbrand, A. V. and Necheles, T. F. 1968. Mechanism of folate deficiency in patients receiving phenytoin. Lancet, ii, 528.
Hoffbrand, A. V., Necheles, T. F., Maldonado, N., Horta, E. and Santini, R. 1969. Malabsorption of folate polyglutamates in tropical sprue. Brit. med. J., ii, 543.
Hoffbrand, A. V., Stewart, J. S., Booth, C. C. and Mollin, D. L. 1968. Folate deficiency in Crohn's disease: Incidence, pathogenesis and treatment. Brit. med. J., ii, 71.
Hoffbrand, A. V., Douglas, A. P., Fry, L. and Stewart, J. S. 1970. Malabsorption of dietary folate (pteroylpolyglutamates) in adult coeliac disease and dermatitis herpetiformis. Brit. med. J., iv, 85.
Hoffbrand, A. V. 1971. The Megaloblastic Anaemias. In Recent Advances in Haematology, edited by Goldberg and Brain.
Houlihan, C. M. and Scott, J. M. 1972. The identification of pteroylpentaglutamate as the major folate derivative in rat liver and the demonstration of its biosynthesis from exogenous (3H) pteroylglutamate. Biochem, Biophys. Research Commun., 48, 1,675.
Houlihan, C. M., Scott, J. M., Boyle, P. H. and Weir, D. G. 1972. The effect of phenytoin on the aborption of synthetic folic acid polyglutamate. Gut, 13, 189.
Hourihane, B., Coyle, C. V. and Drury, M. I. 1960. Megaloblastic anaemia of pregnancy. J. Ir. med. Ass., 47, 1.
Hourihane, D. O'B., and Weir, D. G. 1970. Suppression of erythropoiesis by alcohol. Brit. med. J., i, 86.
Jandl, J. H., 1955. The anaemia of liver disease; observations on its mechanism. J. clin. Invest., 34, 390.
Jandl, J. H. 1958. Haematologic changes in chronic liver disease. Amer. J. Gastroent., 30, 46.
Jandl, J. H. and Greenberg, M. S. 1959. Bone marrow failure due to relative nutritional deficiency in Cooley's haemolytic anaemia. New Eng. J. Med., 260, 461.
Kimber, C., Deller, D. J., Ibbotson, R. N. and Lander, H. 1965. The mechanism of anaemia in chronic liver disease. Quart. J. Med., 133, 33.
Klipstein, F. A. 1964. Subnormal serum folate and macrocytosis associated with anticonvulsant drug therapy. Blood, 23, 68.
Lanzkowsky, P. 1970. Congenital malabsorption of folate. Amer. J. Med., 48, 580.
Leslie, A. L. and Rowe, P. B. 1972. Folate binding by the brush border membrane proteins of small intestinal epithelial cells. Biochem., 11, 1,696.
Lindenbaum, J. and Klipstein, F. A. 1964. Folic acid clearance and basal serum folate levels in patients with thyroid disease. J. clin. Path., 17, 666.
Mannheimer, E., Pakesch, F. and Reimer, E. E. 1952. Die hamatologischen konplikationen der epilepsiebehandlung mit hydentoinkorpern. Medsche. Klin., 47, 1,397.
Maxwell, J. D., Hunter, J., Stewart, D. A., Ardeman, S. and Williams, R. 1972. Folate deficiency after anticonvulsant drugs. An effect of hepatic enzyme induction. Brit. med. J., i, 297.
Melikian, V., Paton, A., Leeming, R. J. and Portman-Graham, H. 1971. Site of reduction and methylation of folic acid in man. Lancet, ii, 955.
Meynell, M. J. 1966. Megaloblastic anaemia in anticonvulsant therapy. Lancet, i, 487.
Mylotte, M., Egan-Mitchell, B., McCarthy, C. F., McNicholl, B. 1973. Incidence of coeliac disease in the west of Ireland. Brit. med. J., i, 212.
McLennan, W. J., Andrews, G. R., McLead, C., Caird, F. I. 1972. Anaemia in the elderly. Quart. J. Med., 42, 1.
Perry, J. and Chanarin, I. 1970. Intestinal absorption of reduced folate compounds in man. Brit. J. Haemat., 18, 329.
Perry, J. and Chanarin, I. 1972. Obervations on folate absorption with particular reference to folate polyglutamate and possible inhibitors to its absorption. Gut, 13, 544.
Perry, J. and Chanarin, I. 1973. Formylation of foliate as a step in physiological folate absorption. Brit. med. J., ii, 588.
Pratt, R. F. and Cooper, B. A. 1971. Folates in plasma and bile of man after feeding folic acid —3H and 5 formyltetrahydrofolate (folinic acid). J. clin. Invest., 50, 455.
Roberts, P. D., Hoffbrand, A. V. and Mollin, D. L. 1966. Iron and folate metabolism in tuberculosis. Brit. med. J., ii, 198.
Rosenberg, I. H., Godwin, H. A., Streiff, R. R. and Castle, W. B. 1968. Impairment of intestinal conjugation of dietary folate. A possible explanation of megaloblastic anaemia associated with phenytoin therapy. Lancet, ii, 9.
Rosenberg, I. H. and Godwin, H. A. 1971. The digestion and absorption of dietary folate. Gastroenterology, 60, 445.
Shapiro, J., Alberts, H. W., Welch, P. and Metz, J. 1965. Folate and vitamin B12 deficiency associated with lactation. Brit. J. Haemat., 11, 498.
Sheridan, D. and Temperley, I. J. 1973. To be published.
Shuster, S., Watson, A. J. and Marks, J. 1967. Folic acid deficiency in patients with skin disease. Brit. J. Haemat., 79, 398.
Smith, M. E., Matty, A. J. and Blair, J. A. 1970. The transport of pteroylglutamic acid across the small intestine of the rat. Biochem. Biophys. Acta., 219, 37.
Stebbins, R., Scott, J. M. and Herbert, V. 1973. Drug induced megaloblastic anaemias. Seminars in Haematology, 10, 235.
Stevens, F. M., Lloyd, R., Egan-Mitchell, B., McNicholl, B., Wright, R. and McCarthy, C. F. 1973. Antireticulin antibodies in coeliacs and their relatives. Gut, 14, 829.
Stewart, J. S., Pollock, D. J., Hoffbrand, A. V., Mollin, D. L. and Booth, C. C. 1967. A study of proximal and distal intestinal structure and absorptive function in ideopathic steatorrhoea. Quart. J. Med., 36, 425.
Strum, W., Nixon, P. F. and Bertino, J. B. 1971. Intestinal folate absorption. 1. 5-Methyltetra-hydrofolic acid. J. clin. Invest., 50, 1,910.
Sullivan, L. W. and Herbert, V. 1964. Supression of haematopoiesis by ethanol. J. clin. Invest., 43, 2,048.
Temperley, I. J., Meehan, M. J. M. and Gatenby, P. B. B. 1968. Serum folic acid levels in pregnancy and their relationship to megaloblastic marrow change. Brit. J. Haemat., 14, 13.
Tomkin, G. H. and Weir, D. G. 1972. Indicanuria after gastric surgery. Quart. J. Med., 41, 191.
Webb, M. G. T., Moore, J. N. P. and Weir, D. G. 971. Diagnosis of vitamin B12 deficiency in psychiatric patients. J. Ir. med. Ass., 64, 417.
Weir, D. G. and Gatenby P. B. B. 1963. Anaemia following gastric operations for peptic ulceration in Dublin. 1. Incidence. Ir. J. med. Sci., 6, 447, 105.
Weir, D. G., Temperley, I. J. and Gatenby, P. B. B. 1963. Anaemia following gastric operations for peptic ulceration in Dublin. 2. Deficiency of iron and vitamin B12. Ir. J. med. Sci., 6, 447, 151.
Weir, D. G., Temperley, I. J. and Gatenby, P. B. B. 1966. Vitamin B12 deficiency following partial gastrectomy. Ir. J. med. Sci., 6, 483, 97.
Weir, D. G. 1968. Recovery of villous architecture in gluten enteropathy exacerbated by gastro-jejunal anastomosis. Postgrad med. J., 44, 234.
Weir, D. G., Brown, J. P., Freedman, D. S. and Scott, J. M. 1973. The absorption of the diastereoisomers of 5 methyltetrahydropteroylglutamate in man. A carrier mediated process. Clin. Sci. 45, 625.
Weir, D. G. and Hourihane, D.O'B. 1974. Coeliac disease in the teenage period; the value of serial serum folate levels. In press.
Weir, E. K., Novis, B., Marsks, S. and Bank, S. 1972. Tropical sprue in the Bantu. South. Afr. med. J., 46, 17.
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The Graves Lecture, 1973.
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Weir, D.G. The pathogenesis of folic acid deficiency in man. Ir J Med Sci 143, 3–20 (1974). https://doi.org/10.1007/BF03004735
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DOI: https://doi.org/10.1007/BF03004735