Conclusion
As an adjunct to general anaesthesia, the technique of using topical lidocaine on the tracheobronchial mucosa is effective and reliable and obtunds laryngeal reflexes. The blood concentrations are dose dependent and in the dosage used (3 mg/kg), the blood concentrations are below toxic levels and are safe.
RéSUMé
Comme adjuvant à ľanesthésie générale, ľusage de la lidocaïne topique sur la muqueuse trachéobronchique est efficace et mérite qu’on s’y arrête; cette technique émousse les réflexes laryngés. Les concentrations dans le sang dépendent de la dose; dans le dosage que nous avons utilisé (3 mg/kg), les concentrations sanguines sont inférieures aux niveaux toxiques et sans danger.
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References
Astra Pharmaceuticals (Canada) Ltd. Xylocaine Endotracheal Aerosol.
Foldes, F. F.;Malloy, R.;McNall, R. G.; &Koubral, L. R. Comparison of Toxicity of Intravenously Given Local Anaesthetic Agents in Man. J.A.M.A.172: 1493 (1960).
Bromage, P. R. &Robson, J. G. Concentration of Lignocaine in Blood after Intravenous, Intramuscular, Epidural and Endotracheal Administration. Anaesthesia.16: 461 (1961).
Porush, I.;Theil, C. G.; &Young, J. G. Pressurized Pharmaceutical Aerosols for Inhalation Therapy: II. Analytical Control Methods. J. Am. Pharm. Assoc.49: 70 (1960).
Contractor, A. M.;Shangraw, R. F.; &Richman, M. D. Aerosol Metering Valves. Drug & Cosmetic Industry.105: 44 (1969).
Keenaghan, J. B. The Determination of Lidocaine and Prilocaine in Whole Blood by Gas Chromatography. Anesthesiology.29: 110 (1968).
Thomas, J.;Long, G.; &Mather, L. E. Plasma Lignocaine Concentrations Following Topical Aerosol Application. Brit. J. Anaesth.41: 5 (1969).
Gianelly, R.;Von Der Groeben, J. O.;Spiracki, A.; &Harrison, D. C. Effect of Lidocaine on Ventricular Arrhythmias in Patients with Coronary Heart Disease. New England J. Med.277: 1215 (1967).
Adriani, J. &Campbell, D. Fatalities Following Topical Application of Local Anaesthetics to Mucous Membranes. J.A.M.A. 162: 1527 (1956).
Tomashefski, J. F.;Nelson, S. W.; &Christoforedis, A. J. Oropharyngeal and Tracheobronchial Aerosol. Anaesthesia, Dis. Chest.42: 181 (1962).
Corssen, G. &Allen, C. R. Cultured Human Respiratory Epithelium: Its Use in the Comparison of the Cytotoxic Properties of Local Anesthetics. Anesthesiology.21: 3 (1960).
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Pelton, D.A., daly, M., Cooper, P.D. et al. Plasma lidocaine concentrations following topical aerosol application to the trachea and bronchi. Can. Anaesth. Soc. J. 17, 250–255 (1970). https://doi.org/10.1007/BF03004603
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DOI: https://doi.org/10.1007/BF03004603