Skip to main content

The use of pancuronium bromide in patients receiving lithium carbonate

Summary

A surgical patient receiving lithium carbonate therapy is presented, in whom the use of the non-depolarizing muscle relaxant pancuronium bromide produced prolonged neuromuscular blockade. Possible mechanism of action involves impaired ACH synthesis and release. The physiology and pharmacology of lithium bromide are discussed.

Résumé

Nous présentons un cas de chirurgie où le malade recevait du carbonate de lithium, chez qui le bromure de pancuronium, un myorésolutif non dépolarisant, a produit un blocage neuromusculaire prolongé. Le mécanisme ďaction possible implique la synthèse et la libération de ľacétylcholine. Nous discutons la physiologie et la pharmacologie du bromure de lithium.

Bibliography

  1. Baastrup, P.C. &Schon, M. Lithium as a prophylactic agent. Its effect against recurrent depressions and manic-depressive psychosis. Arch. Gen. Psychiat. (Chicago).16: 162–172 (1967).

    PubMed  CAS  Google Scholar 

  2. Angst, J., Dittrich, A., &Goof, P. Course of endogenous affective psychosis and its modification by prophylactic administration of imipramine and lithium. Int. Pharmacophychiat.2: 1–11 (1969).

    Google Scholar 

  3. Schose, M. Lithium in psychiatric therapy and phophylaxis. J. Psychiat. Res.6: 67–95 (1968).

    Article  Google Scholar 

  4. Gershon, S. Lithium in mania. Clin. Pharmacol. Ther.11: 168–187 (1970).

    PubMed  CAS  Google Scholar 

  5. Maggs, R. Treatment of manic illnesses with Lithium carbonate. Brit. J. Psychiat.109: 56–65 (1963).

    Article  Google Scholar 

  6. Noyes, R.,Jr. Lithium carbonate: a review. Dis. Neur. Syst.30: 318–21 (1969).

    Google Scholar 

  7. Gershon, S. Lithium in mania. Clinical Pharm. and Ther.11: 168–185 (1970).

    CAS  Google Scholar 

  8. Gergis, S.D. Effect of pancuronium bromide on acethycholine release. Proc. Soc. Exp. Biol. Med.139: 74–76 (1972).

    PubMed  CAS  Google Scholar 

  9. Sohn, Y.J. &Aldrete, J. A. Prejunctional effects of pancuronium bromide at the cat soleus neuromuscular junction. Fed. Proc. Fed. Amer. Soc. Exp. Biol.30: 557 (1971).

    Google Scholar 

  10. Foldes, F.F., Klonymus, D.H., Maisel, W., Sciammas, F., &Pan, T. Studies of pancuronium in conscious and anesthetized man. Anesthesiology35: 496–503 (1971).

    PubMed  Article  CAS  Google Scholar 

  11. Vizi, E.S. Illes, P.,Ronai, A., &Knoll, J. The effect of lithium on acetylcholine release and synthesis. Neuropharm.11: 521–530 (1972).

    Article  CAS  Google Scholar 

  12. Paton, W.D.M., Vizi, E.S., &Far, O. The mechanism of acetylcholine release from parasympathetic nerves. J. Physiol. Lon.215: 819–848 (1971).

    CAS  Google Scholar 

  13. Katz, R., Chase, N., &Kapin, I.J. Evoked release of norepinephrine and serotonine from brain slices: inhibition by lithium. Science, N.Y.162: 466–467 (1968).

    CAS  Google Scholar 

  14. Platman, S., Rohrlich, J., &Fieve, R. Absorption and excretion of lithium in manicdepressive disease. Dis. Nerv. Syst.29: 733–38 (1968).

    PubMed  CAS  Google Scholar 

  15. Allgen, L.G. Laboratory experience of lithium toxicity in man. Acta psychiat. Scand.207: 9–104 (1969).

    Google Scholar 

  16. Platman, S.R. &Fieve, R.R. Lithium retention and excretion. The effect of sodium and fluid intake. Arch. Gen. Psychiat. (Chicago)20: 285–289 (1969).

    PubMed  CAS  Google Scholar 

  17. Walts, L.F. &Dillon, J.B. Deviations of action of ďtubocurarine and gallamine. Anesthesiology29: 499–504 (1968).

    PubMed  CAS  Article  Google Scholar 

  18. Walts, L.F., Lebowitz, M., &Dillon, J.B. The effect of ventilation on the action of tubocurarine and gallamine. Brit. J. Anesth.39: 845–849 (1967).

    Article  CAS  Google Scholar 

  19. Norman, J., Katz, R.L., &Seed, R.F. Neuromuscular blocking action of pancuronium in man.42: 702–709 (1970).

    CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Borden, H., Clarke, M.T. & Katz, H. The use of pancuronium bromide in patients receiving lithium carbonate. Can. Anaesth. Soc. J. 21, 79–82 (1974). https://doi.org/10.1007/BF03004581

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF03004581

Keywords

  • Lithium
  • Pancuronium
  • Gallamine
  • Pancuronium Bromide
  • Lithium Bromide