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The use of pancuronium bromide in patients receiving lithium carbonate


A surgical patient receiving lithium carbonate therapy is presented, in whom the use of the non-depolarizing muscle relaxant pancuronium bromide produced prolonged neuromuscular blockade. Possible mechanism of action involves impaired ACH synthesis and release. The physiology and pharmacology of lithium bromide are discussed.


Nous présentons un cas de chirurgie où le malade recevait du carbonate de lithium, chez qui le bromure de pancuronium, un myorésolutif non dépolarisant, a produit un blocage neuromusculaire prolongé. Le mécanisme ďaction possible implique la synthèse et la libération de ľacétylcholine. Nous discutons la physiologie et la pharmacologie du bromure de lithium.


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Borden, H., Clarke, M.T. & Katz, H. The use of pancuronium bromide in patients receiving lithium carbonate. Can. Anaesth. Soc. J. 21, 79–82 (1974).

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  • Lithium
  • Pancuronium
  • Gallamine
  • Pancuronium Bromide
  • Lithium Bromide