Summary and Conclusions
The present study was undertaken to evaluate the effect of meperidine alone and of meperidine-supplemented nitrous oxide anaesthesia on adrenocortical function, as judged by their influence on plasma free Cortisol levels in 30 patients undergoing operation. In conformity with its relatively insufficient sedative effect, meperidine administered intramuscularly (2 mg/kg) one hour prior to induction of anaesthesia did not inhibit adrenocortical stimulation due to emotional stress. Meperidine-nitrous-oxide anaesthesia alone for 30 minutes did not stimulate adrenocortical activity, but could not block adrenocortical stimulation during surgical intervention and after operation.
Résumé
La présente étude a été entreprise pour évaluer ľeffet de la mépéridine seule ou de ľanesthésie au protoxyde ďazote additionné de mépéridine sur la fonction cortico-surrénalienne selon leur influence sur les niveaux de Cortisol libre de plasma, chez 30 sujets subissant une opération. Conformément à son effet sédatif relativement insuffisant, la mépéridine administrée par voie intra-musculaire (2 mg/kg) une heure avant ľinduction de ľanesthésie n’a pas empêché la stimulation cortico-surrénalienne due au stress émotionnel. Ľanesthésie seule au protoxyde ďazote-mépéridine durant 30 minutes n’a pas stimulé ľactivité adréno-corticale, mais elle n’a pas pu bloquer la stimulation adréno-corticale pendant et après ľopération.
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Oyama, T., Takiguchi, M., Takazawa, T. et al. Effect of meperidine on adrenocortical function in man. Can. Anaes. Soc. J. 16, 282–291 (1969). https://doi.org/10.1007/BF03004456
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DOI: https://doi.org/10.1007/BF03004456