Conclusion
Chez les sujets âgés, le reflux est une maladie très commune responsable d’une morbidité non négligeable. Chez eux, le reflux est habituellement plus sévère que chez le sujet jeune, trop souvent sous évalué et sous traité. Le maintien d’un traitement continu par les IPP est souvent nécessaire compte tenu de la sévérité des lésions secondaires au RGO.
Similar content being viewed by others
Références
Locke GR. Talley NJ, Fett SR, Zinsmeister AR, Melton LJ. Prevalence and clinical spectrum of gastroesophageal reflux: a population based study in Olmsted County Minnesota Gastroenterology 1997; 112: 1448–56.
Richter JE. Gastroesophageal reflux disease in the older patient: presentation treatment and complications. Am J Gastroenterol 2000; 95: 368–73.
Zhu H Pace F, Sangaletti O et al. Features of symptomatic gastroesophageal reflux in elderly patients Scand J Gastroenterol 1993; 28: 235–8.
Collen MJ, Abdulian JD, Chen YK Gastroesophageal reflux disease in the elderly: more severe disease that requires aggressive therapy. Am J Gastroenterol 1995; 90: 1053–7.
Johnson DA, Fennerty MB. Heartburn severity underestimates erosive esophagitis severity in elderly patients with gastroesophageal reflux disease. Gastroenterology 2004; 126: 660–4.
El-Serag HB, Sonnenberg A. Association between different forms of gastroesophageal reflux disease. Gut 1997; 41: 594–9.
Triadafilopoulos G, Sharma R. Features of symptomatic gastroesophageal reflux disease in elderly patients. Am J Gastroenterol 1997; 92: 2007–11.
Roblin X. Les pneumopathies d’inhalation. In : Kotzki N, Pouderoux Ph, Jacquot JM, eds. Les troubles de la déglutition. Paris Masson 1999: 55–62.
Tack J, Vantrappen G. The aging oesophagus. Gut 1997; 41: 422–4.
Achem SR and Devault KR. Dysphagia in aging. J Clin Gastroenterol 2005: 39: 357–71.
Goldschmiedt M, Barnett CC, Schwarz BE, Karnes WE, Redfern JS, Feldman. Effect of age on gastric acid secretion and serum gastrin concentrations in healthy men and women. Gastroenterology 1991; 101: 977–90.
Pierson H, Preiss MA, Jeandel C, Pénin F, Cuny G. Oesophagite du sujet âgé. Etude prospective dans un service de médecine interne gériatrique. Ann Gastroenterol Hépatol 1988; 24: 97–101.
Raiha I, Hietanen E, Sourander L. Symptoms of gastro-oesophageal reflux disease in elderly people. Age and Ageing 1991; 20: 365–70.
Fass R, Offman JJ. Gastroesophageal disease: should we adopt a new conceptual framework? Am H Gastroenterol 2002; 97: 1901–9.
Avidan B, Sonnenberg A, Schnell TG, Budiman EB, Sontag SJ. Risk factors of oesophagitis in athritic patients. Eur J Gastroenterol Heptalo 2001; 13: 1095–9.
Raïha I, Impivaara O, Seppälä M, Knuts LR, Sourander. Determinants of symptom suggestive of gastroesophageal reflux disease in the elderly. Scand J Gastroenterol 1993; 28: 1011–14.
Raiha I, Manner R, Hietanen E, Hartiala J, Sourander LB. Radiographic pulmonary changes of gastro-oesophgeal reflux disease in elderly patients Age and Ageing 1992; 21: 250–55.
Raiha I, Ivaska K, Sourander LB. Pulmonary function in gastro-oesophageal reflux disease of elderly people. Age and Ageing 1992; 21: 368–73.
Goyal RK, Glancy JJ, Spiro HM. Lower esophageal ring. N Engl J Med 1970; 282:1298–1305 et 1355–1362.
Costa ND, Cadiot G, Merle C, Jolly D, Bouche O, Thiefin G, Zeitoun P.
Costa ND, Cadiot G, Merle C, Jolly D, Bouche O, Thiefin G, Zeitoun P. Bleeding reflux esophagitis: a prospective 1-year study in a university hospital Am J Gastroenterol 2001 ; 96: 47–51.
Whitaker M. Proton pump inhibitors in the elderly population. Eur J Gastroenterol Hepatol 2002, 14 (suppl 1): S5-S9.
De Korwin JD, Ducrotté Ph, Vallot Th. Les nouveaux IPP: un progrès dans la prise en charge des maladies acido-peptiques? La Presse Médicale 2004; 33: 746–54.
Sachs G. Improving on PPI-based therapy of GORD. Eur J Gastroenterol Hepatol 2001; 13(suppl 1): S35-S41.
Pantoflickova D, Dorta G, Ravic M, Jornod P, Blum AL. Acid inhibition on the first day of dosing: comparison of four proton pump inhibitors. Aliment Pharmacol Ther 2003; 17: 1507–14.
Warrington S, Baisley K, Boyce M, Tejura B, Morocutti A, Miller N. Effects of rabeprazole 20 mg, or esomeprazole 20 mg, on 24-h intragastric pH and serum gastrin in healthy subjects. Aliment Pharmacol Ther 2002; 16: 1301–7.
Baisley K, Warrington S, Tejura B, Morocutti A, Miller N. Rabeprazole 20 mg compared with esomeprazole 40 mg in the control of intragastric pH in healthy volunteers. J Gastroenterol Hepatol 2002; 17(suppl): A845 (abstract).
Robinson M, Maton PN, Rodriguez S, Greenwood B, Humphries TI. Effects of oral rabeprazole on oesophageal and gastric pH in patients with gastrooesophageal reflux disease. Aliment Pharmacol Ther 1997; 11: 973–80.
Spera AC, Humphries TJ, Merritt J, Laurent A. No dosage adjustment is required when rabeprazole sodium 20 mg is administered once daily to elderly patients Gastroenterology 1997; 112: A908.
Keane WF, Swan SK, Grimes I, Humphries TJ. Rabeprazole: pharmacokinetics and tolerability in patients with stable endstage renal failure. J Clin Pharmacol 1999; 39: 927–33.
Hoyumpa AM, Trevino-Alaris H, Grimes I, Humphries TJ. Rabeprazole: pharmacokinetics in patients with stable, compensated cirrhosis Clin Ther 1999; 21: 691–701.
Ishizaki T, Horai Y. Review article: cytochrome P450 and the metabolism of proton pump inhibitors — emphasis on rabeprazole. Aliment Pharmacol Ther 1999; 13(suppl 3): 27–36.
Humphries TJ, Merritt GJ. Review article: drug interactions with agents used to treat acid-related diseases. Aliment Pharmacol Ther 1999; 13(suppl 3): 18–26.
Humphries TJ, Nardi RV, Lazar JD, Spanyers SA. Drug-drug interaction evaluation of rabeprazole sodium: A clean/expected slate? Gut 1996; 39(suppl 3): A47 (Abstract).
Andersson T, Hassan-Alin M, Hasselgren G, Rohss K. Drug interaction studies with esomeprazole, the (S)-isomer of omeprazole. Clin Pharmacokinet 2001; 40: 523–37.
Robinson M, Fitzgerald S, Hegedus R, Murthy et al Onset of symptom relief with rabeprazole: a community-based, openlabel assessment of patients with erosive esophagitis. Aliment Pharmacol Ther 2002: 16: 445–54.
Author information
Authors and Affiliations
About this article
Cite this article
Vallot, T. Le reflux gastro-œsophagien du sujet âgé: données générales et place du rabéprazole dans la prise en charge thérapeutique. Acta Endosc 35, 389–394 (2005). https://doi.org/10.1007/BF03003288
Issue Date:
DOI: https://doi.org/10.1007/BF03003288