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Prognostic features at diagnosis of chronic myeloid leukaemia with special emphasis on histological parameters

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Abstract

A clinicopathological study was performed on 115 patients (56 males, 59 females; median age 48 yr) with chronic myeloid leukaemia (CML) to reveal initial clinical, but particularly histomorphological features of predictive value for survival. All patients had a trephine biopsy of the bone marrow and entered this study without prior selection. Overall survival was 36 ± 27 months. In addition to multiple interactions between various disease features, multivariate regression analysis showed that of the clinical parameters age, liver size and level of LDH were primarily and most closely associated with prognosis. Of the histomorphological variables, megakaryocytes > 60 mm−2 bone marrow area and fibrosis displayed an unfavourable impact on survival on univariate calculation. On multivariate analysis, however, only pseudo-Gaucher cells remained significant, i.e. exerted an independent and favourable influence on prognosis. Histological features of predictive value were reviewed together with the different categories of a histopathological classification proposed for chronic myeloproliferative diseases by Georgii and co-workers.13

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Authors and Affiliations

  1. Institute of Pathology, University of Cologne, West Germany

    Jürgen Thiele, Carmen Thienel & Robert Fischer

  2. First Clinic of Medicine, University of Cologne, West Germany

    Rudolf Zankovich

Authors
  1. Jürgen Thiele
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  2. Carmen Thienel
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  3. Rudolf Zankovich
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  4. Robert Fischer
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Supported in part by a grant from the Moritz Foundation, Cologne, West Germany.

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Thiele, J., Thienel, C., Zankovich, R. et al. Prognostic features at diagnosis of chronic myeloid leukaemia with special emphasis on histological parameters. Med. Oncol. & Tumor Pharmacother. 5, 49–60 (1988). https://doi.org/10.1007/BF03003181

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  • DOI: https://doi.org/10.1007/BF03003181

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