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A polyamine formaldehyde resin IV. Clinical evaluation in the treatment of duodenal ulcer

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The American Journal of Digestive Diseases

Summary and Conclusions

The literature concerning the use of an anion exchange resin in the treatment of peptic ulcer has been reviewed.

Laboratory data presented suggest that the average dose necessary to elevate the gastric pH consistently is 2 gm. of the powdered resin. Smaller doses may be efficacious because of the possible favorable effect upon the critical pH and pepsin activity in the first part of the duodenum.

A clinical remission of the ulcer symptoms occurred in 17 of 26 duodenal ulcer patients treated with this anion exchange resin. In three patients the symptoms were relieved only as long as the resin was used.

Relief of symptoms occurred in 5 of 15 patients with complications. No clinical remission took place in any of these 15 patients, all of whom came to surgery.

Practically no adverse side effects occurred with the administration of this resin.

This anion-exchange resin appears to be a useful antacid in the therapy of duodenal ulcer.

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Author notes

  1. Eldon E. Ellis M.D.

    Present address: Department of Surgery, Stanford University Hospital, San Francisco, California

Authors and Affiliations

  1. Rochester, N. Y.

    Harry L. Segal M.D., Harold A. Friedman M.D., Eldon E. Ellis M.D. & James S. Watson M.D.

Authors
  1. Harry L. Segal M.D.
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  2. Harold A. Friedman M.D.
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  3. Eldon E. Ellis M.D.
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  4. James S. Watson M.D.
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Additional information

From the Departments of Medicine and Roentgenology, the Strong Memorial, the Rochester Municipal, and Genesee Hospitals—the University of Rochester School of Medicine and Dentistry, Rochester, New York.

The resin used in the present study was supplied by the Medical Research Department of the National Drug Company of Philadelphia, Pennsylvania. This 200 mesh resin had been named Resinat by the National Drug Company and appears for the first time under that name in the work of Spears and Pfeiffer. (7) The capsules used in this study contained Amberlite XE-43, which has now been discarded. The resin now used in Resinat capsules is designated as Amberlite XE-58. It is a finer mesh resin and should be more efficacious than the capsules available for this study.

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Segal, H.L., Friedman, H.A., Ellis, E.E. et al. A polyamine formaldehyde resin IV. Clinical evaluation in the treatment of duodenal ulcer. Amer. Jour. Dig. Dis. 17, 293–296 (1950). https://doi.org/10.1007/BF03002545

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