Conclusions
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1.
We have prepared stable colloidal phenolphthalein in solid form.
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2.
Colloidal phenolphthalein strikes a pink color with sodium bicarbonate solution (pH 8).
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3.
Colloidal phenolphthalein is considerably more soluble than is crystalline phenolphthalein at the hydrogen ion concentrations prevailing in the human body.
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4.
Colloidal phenolphthalein has a bitter taste.
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5.
Colloidal phenolphthalein may pass through the stomach, providing it is not detained in exposure to active gastric juice for an excessive length of time.
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6.
Colloidal phenolphthalein is somewhat more active in producing bowel evacuation than is the crystalline form.
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From the Laboratory of Pharmacology and Therapeutics of the College of Medicine, University of Illinois, and assisted by a grant from Phenolphthalein Research, Inc.
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Fantus, B., Dyniewicz, J.M. Phenolphthalein studies. American Journal of Digestive Diseases and Nutrition 2, 721–724 (1935). https://doi.org/10.1007/BF03002435
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DOI: https://doi.org/10.1007/BF03002435