Summary
Succinylcholine (20 mg.) was administered to alcoholic patients as part of a conditioned aversion therapy against alcohol. No anaesthesia was used. The effects of succinylcholine on respiration, heart rate, skin resistance, and muscle tension were recorded. A marked bradycardia was consistently observed during the period of apnoea.
In three subjects these observations were repeated combining the injection of thiopentone (0.4 gm.) with succinylcholine (20 mg.). No bradycardia appeared and the period of apnoea was shorter than when the succinylcholine was given alone.
Résumé
Nous avons donné de la succinylcholine (20 mg.) à des alcooliques comme partie ďun traitement destiné à provoquer de ľaversion pour ľalcool. Nous n’avons pas employé ďanesthésie. Nous avons enrégistré les effets de la succinylchpline sur la respiration, le rythme cardiaque, la résistance de la peau et le tonus musculaire. De faÇon constante, durant la période ďapnée, nous avons noté une bradycardie marquée.
Chez trois malades, nous avons repris notre étude en asiociant du thiopentone (0.4 gm.) à la succinylcholine (20 mg.). Nous n’avons plus observé de bradycardie et la période ďapnée a été plus courte que lorsque la succinylcholine était donnée seule.
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References
Sanderson, R. E.; Campbell, D.; & Laverty, S. G. An Investigation of a New Aversive Conditioning Treatment for Alcoholism (in preparation).
Holmberg, G., &Thesleff, S. Succinylcholine as Muscle Relaxant in Electroshock Therapy. Nordisk. Med.46: 1567–1569 (1951).
Barreto, R. S. Effect of Intravenously Administered Succinylcholine upon Cardiac Rate and Rhythm. Anesthesiology21: 401–404 (1960).
Bullough, J. Intermittent Suxamethonium Injections. Brit. Med. J.1: 786–787 (1959).
Becker, W. C. &Matteson, H. H. GSR Conditioning, Anxiety, and Extraversion. J. Abnorm. Soc. Psychol.62: 427–430 (1961).
Leigh, M.;Digby, G.;McCoy, P. D.;Belton, K. M.; &Lewis;G. B. Jr. Bradycardia Following Intravenous Administration of Succinylcholine Chloride to Infants and Children. Anesthesiology18: 698–702 (1959).
Kalow, W.In Relaxants, in Uptake and Distribution of Anesthetic Agents,edited by E. M. Papper and R. J. Kitz, pp. 302–313. New York: McGraw Hill Publishing Company (1963).
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Vandewater, S.L., Laverty, S.G., Campbell, D. et al. Some effects of succinylcholine chloride in conscious human subjects. Can. Anaes. Soc. J. 10, 508–515 (1963). https://doi.org/10.1007/BF03002078
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DOI: https://doi.org/10.1007/BF03002078