Abstract
Repeated EEG and ECG monitoring during sleep was carried out in two subjects with ischemic heart disease and one presumably healthy control. All three displayed frequent ectopic heart beats. Two had ventricular and the third atrial premature beats.
The study had two objectives: (1) to ascertain the distribution of ectopic beats among the stages of sleep; and (2) to ascertain the effect of alcohol and barbiturates on the frequency of premature beats. Both drugs are known to alter the pattern of sleep stages. It was found that neither atrial nor ventricular premature beats favored a particular sleep stage. Neither drug had a consistent effect on their frequency and there was no correlation with heart rate. For the most part premature beats were fewer on the second night of a procedure although a day filled with anxiety appeared to greatly increase the frequency of premature contractions.
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References
Baekeland, F.: Pentobarbital and dextroamphetamine sulphate: Effects on the sleep cycle in man.Psychopharmacologia (Berlin),11:388–396, 1967.
Bond, W. C., Bohs, C., Ebey, J., Jr., and Wolf, S.: Rhythmic heart rate variability (sinus arrhythmia) related to stages of sleep.Cond. Reflex,8:98–107, 1973.
Burdick, J. A., Brinton, G., Goldstein, L., and Laszlo, M.: Heart-rate variability in sleep and wakefulness.Cardiology,55:79–83, 1970.
Hiss, R. G., and Lamb, L. E.: Electrocardiographic findings in 122,043 individuals.Circulation,25:947–961, 1962.
Jouvet, M., Michel, F., and Mounier, D.: Analyse electroencephalographique comparee du sommeil physiologique chez le chat et chez l’homme.Rev. Neurol.,103: 189–305, 1960.
Lester, B. K., and Block, R. T.: Cardiac rate and rhythm during sleep in patients with ischemic heart disease. To be published.
Nowlin, J. B., Troyer, W. G., Jr., Collins, W. S.,et al.: The association of nocturnal angina pectoris with dreaming.Ann. Intern. Med.,63:1040–1046, 1965.
Rechtschaffen, A., and Kales, A.: A manual of standardized terminology, techniques and scoring system for sleep stages of human subjects. Public Health Service, U.S. Government Printing Office, Washington, D. C., 1967.
Snyder, F., Hobson, J. A., Morrison, D. F., and Goldfrank, R.: Changes in respiration, heart rate, and systolic blood pressure in human sleep.J. Appl. Physiol.,19:417–422, 1964.
Wolf, S.: Central autonomic influences on cardiac rate and rhythm.Mod. Concepts Cardiovasc. Dis.,38:29–34, 1969.
Yules, R. B., Freedman, D. X., and Chandler, K. A.: The effect of ethyl alcohol on man’s electroencephalographic sleep cycle.Electroenceph. Clin. Neurophysiol.,20:109–111, 1966.
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Feinstein, R., Gooden, B.A. & Wolf, S. The effect of alcohol and barbiturate on the frequency of atrial and ventricular premature beats during sleep. Pav. J. Biol. Sci. 10, 102–111 (1975). https://doi.org/10.1007/BF03001154
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DOI: https://doi.org/10.1007/BF03001154