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Adrenergic potentiation, a pharmacodynamic effect associated with antihistaminic agents

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The American Journal of Digestive Diseases

Summary

An important pharmacodynamic action of certain compounds known as “antihistaminic agents” is that of adrenergic potentiation. Ths feature has been demonstrated in reference to the adrenergic control of feline blood pressure, salivation and retraction of the nictitating membrane, and of canine blood pressure and intestinal motility.

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References

  1. Halpern, B. N.: Die Synthetischen Antihistamine. Versuch einer Chemotherapie der allergischen Zustande. Arch. Intern. Pharmacodyn. 68:339, 1942.

    CAS  Google Scholar 

  2. Bovet, D., Horclois, R. and Fournel, J.: Antagonisne exercepar la N-p-methoxy-benzyl_N_dimethylamino_ethyl a aminopyridine sur l’hypothension et la vasodilatation histaminiques. Compt. Rend. Soc. de Biol. 138:165, 1944.

    CAS  Google Scholar 

  3. Loew, E. R., Kaiser, Margaret E. and Moore, V.: Synthetic Benzhydryl Alkamine Ethers Effective in Preventing Fatal Experimental Asthma in Guinea Pigs Exposed to Atomized Histamine. J. Pharmacol. & Exper. Therap. 83:120, 1945.

    CAS  Google Scholar 

  4. Mayer, R. L., Huttrer, C. P. and Scholz, C. R.: Antihistaminic and Antianaphylactic Activity of Some a-Pyridinoethylenediamines. Science 102:92, 1945.

    Google Scholar 

  5. Meier, R. and Bucher, K.: Pharmakologie des 2-(N-phenyl_N_benzyl_amino_ethyl)-imidazolines (Antistin). (Ein neuer synthetischer Antihistaminkorper). Schweiz. Med. Wschr. 76:294, 1946.

    Google Scholar 

  6. Feinstone, W. H., Williams, R. D. and Rubin, B.: Antihistamine and Antianaphylactic Effect of Hetramine, a New Synthetic Pyrimidine Compound. Proc. Soc. Exp. Biol. & Med. 63:158, 1946.

    CAS  Google Scholar 

  7. Yonkman, F. F., Chess, D., Hays, H. W., Rennick, B. and Mayer, R. L.: Adrenergic Potentiation by Pyribenzamine HCl (N′-pyridyl_N′_benzyl_N′-dimethylethylene diamine HCl). Fed. Proc. 5:216, 1946.

    Google Scholar 

  8. Yonkman, F. F., Chess, D., Mathieson, D. and Hansen, N.: Pharmacodynamic Studies of a New Antihistamine Agent, N′-pyridyl_N′_benzyl_N′_dimethylethylene Diamine HCl, Pyribenzamine HCl. I. Effects on Salivation, Nictitating Membrane, Lachrymation, Pupil and Blood Pressure. J. Pharmacol. & Exper. Therap. 87:256, 1946.

    CAS  Google Scholar 

  9. Parrot, J. L.: Sur le Mode d’action des Antagonistes de l’Histamine. Action du Chorhydrete de la N-dimethyl_amino_ethyl-N-benzylaniline (2339 R. P.) sur les effets de l’Adrenaline. Compt. rend. Soc. de Biol. 137:378, 1943.

    CAS  Google Scholar 

  10. Loew, E. R., MacMillan, R., Kaiser, Margaret E.: The Anti-histamine Properties of Benadryl, β-dimethyl-aminoethyl Benzhydryl Ether, Hydrochloride. J. Pharmacol. & Exper. Therap. 86:229, 1946.

    CAS  Google Scholar 

  11. Sherrod, T. R., Schloemer, H. F. and Loew, E. R.: Pharmacological Studies of Antihistamine Compounds. Fed. Proc. 5:202, 1946.

    Google Scholar 

  12. Sherrod, T. R., Loew, E. R. and Schloemer, H. F.: Pharmacological Properties of Antihistamine Drugs, Benadryl, Pyribenzamine and Neoantergan. J. Pharmacol. & Exper. Therap. 89:247, 1947.

    CAS  Google Scholar 

  13. Ambache, N.: Interaction of Drugs and Effect of Cooling on Isolated Mammalian Intestine. J. Physiol. 104:266, 1946.

    PubMed  CAS  Google Scholar 

  14. Craver, B. N. and Cameron, A.: Contributions to an elucidation of the Pharmacological Action of Histamine. Fed. Proc. 6:314, 1947.

    Google Scholar 

  15. Staub, H.: Action Mechanism of Epinephrine. Schweiz. med. Wschr. 76:818, 1946 (Abstract J.A.M.A. 133:353, 1947).

    Google Scholar 

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From the Research Laboratories, Ciba Pharmaceutical Products, Inc., Summit, New Jersey.

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Yonkman, F.F. Adrenergic potentiation, a pharmacodynamic effect associated with antihistaminic agents. Jour. D. D. 14, 360–363 (1947). https://doi.org/10.1007/BF03001112

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  • DOI: https://doi.org/10.1007/BF03001112

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