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The importance of the Vi antigen

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The American Journal of Digestive Diseases

Summary

The characteristics of the Vi antigen present in typhoid bacilli and other Salmonellae was discussed. Vi agglutination experiments failed to produce better results than other diagnostic means. Inoculation with Vi vaccines increased mouse protecting antibodies to a fairly high level. Experiments were carried out in vitro and in mice which showed that typhoid and paratyphoid C bacilli with Vi antigen show a stronger initial multiplication than organisms without the Vi factor. The importance of these findings is discussed.

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References

  1. Felix, A. and Pitt, R. M.: A New Antigen of B. typhosus. Lancet 227:186–191, 1934.

    Article  Google Scholar 

  2. Almon, L. and Stovall, W. D.: A Study of the “Vi” Antigen of Felix and Pitt. J. Immunol. 31:269–284, 1936.

    Google Scholar 

  3. Kauffmann, F.: Uber einen neuen serologischen Formwechsel der Typhusbacillen. Z. Hyg. Infektionskrankh. 116:617–651, 1935.

    Article  Google Scholar 

  4. Bhatnagar, S. S., Speechly, C. G. J. and Singh, M.: A Vi Variant of Salmonella typhi and Its Application to the Serology of Typhoid Fever. J. Hyg. 38:663–672, 1938.

    Article  CAS  Google Scholar 

  5. Peluffo, C. A.: Stability of Vi Antigen of Salmonella typhi. Proc. Soc. Exp. Biol. & Med. 48:340–343, 1941.

    CAS  Google Scholar 

  6. Kauffmann, F.: Die Bakteriologie der Salmonellagruppe. Einar Munksgaard, Copenhagen, 1941.

    Google Scholar 

  7. Almon, L.: The Significance of the Vi Antigen. Bact. Rev. 7:43–56, 1943.

    PubMed  CAS  Google Scholar 

  8. Bhatnagar, S. S.: Phagocytosis of B. typhosus in Relation to Its Antigenic Structure and to the Antibody Components of the Sensitizing Serum. Brit. J. Exp. Path. 16:375–384, 1935.

    CAS  Google Scholar 

  9. Kauffmann, F.: Uber das Vorkommen von Salmonella-Antigenen. Acta Path. Microbiol. Scand. 18:225–246, 1941.

    CAS  Google Scholar 

  10. Ogonuki, H.: On the Vi Antigen of Salmonella paratyphi C. Kitasato Arch. Exp. Med. 17:88–94, 1940.

    CAS  Google Scholar 

  11. Hayes, W. and Freeman, J. F.: The Incidence, Type and Bacteriology of Salmonella Infection in the Army in India. Indian J. M. Res. 33:177–194, 1945.

    Google Scholar 

  12. Bekker, J. H. and Vink, H. H.: Vi Antigen in B. coli and Vi Agglutinin. A. van Leeuwenhoek, 10:12–14, 1944/45.

    Article  Google Scholar 

  13. Longfellow, D. and Luippold, G. F.: The Immunologic Relationship between the V Forms of E. typhosa and S. ballerup. Am. J. Hyg. 37:206–210, 1943.

    Google Scholar 

  14. Luippold, G. F.: The Suitability of Vi Antigen as an Auxiliary Immunogen for Typhoid Vaccines. Am. J. Pub. Health 36:15–25, 1946.

    PubMed  CAS  Google Scholar 

  15. Checcacci, L.: Varianti opache e diagane della S. paratyphi C e della S. ballerup. Giorn. Batter. 28:269–298, 1942.

    Google Scholar 

  16. Brower, E. H.: The Detection of Vi Agglutinins in the Sera of Typhoid Carriers. J. Hyg. 40:154–162, 1944.

    CAS  Google Scholar 

  17. Gunther, C. B.: Studies on the Vi Agglutination Test for the Detection of Typhoid Carriers. Am. J. Clin. Path. 16:293–305, 1946.

    Google Scholar 

  18. Soman, D. W.: The Distribution of Typhoid Vi Agglutinins in Normal Sera with Special Reference to their Diagnostic Value in Typhoid Fever. Indian M. Gaz. 80:90–91, 1945.

    Google Scholar 

  19. Bhatnagar, S. S.: Vi Agglutinins in the Diagnosis of Typhoid Fever and the Carrier Condition. Brit. M. J. 2:1195–1196, 1938.

    Google Scholar 

  20. Felix, A. and Pitt, R. M.: Virulence and Immunogenic Activities of B. typhosus in Relation to Its Antigenic Constituents. J. Hyg. 35:428–436, 1935.

    Google Scholar 

  21. Felix, A.: A New Type of Typhoid and Paratyphoid Vaccine. Brit. M. J. 1:391–393, 1941.

    Google Scholar 

  22. Unpublished data.

  23. Goodall, J. F.: Typhoid Septicemia. Lancet, 247:851–852, 1944.

    Article  Google Scholar 

  24. Henderson, D. W. and Morgan, W. T. J.: The isolation of Antigenic Substances from Strains of Bact. typhosum. Brit. J. Exp. Path. 19:82–94, 1938.

    CAS  Google Scholar 

  25. Topley, W. W. C., Raistrick, H., Wilson, J., Stacy, M., Challinor, S. W. and Clark, R. O. J.: The Immunizing Potency of Antigenic Components Isolated from Different Strains of Bact. typhosum. Lancet 232:252–256, 1937.

    Article  Google Scholar 

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Authors and Affiliations

  1. Chicago, Illinois

    Viola Mae Young M.S. & Oscar Felsenfeld M.D.

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  1. Viola Mae Young M.S.
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  2. Oscar Felsenfeld M.D.
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From the Mount Sinai Medical Research Foundation, Chicago 8, Ill.

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Young, V.M., Felsenfeld, O. The importance of the Vi antigen. Jour. D. D. 14, 349–352 (1947). https://doi.org/10.1007/BF03001110

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  • DOI: https://doi.org/10.1007/BF03001110

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