The treatment of amoebiasis with lodoxyquinolin sulphonic acid

Summary

From six years experience, during which one hundred and fifty–two cases ofE. histolytica infection have been treated, there seems reason to believe that in intestinal amoebiasis iodoxyquinolin sulphonic acid (anayodin) is a very useful drug. It is now shown to be as effective in stopping severe symptoms rapidly and curing acute cases as it is in curing carrier cases. It will not cure all cases any more than any other drug known for the treatment of this infection.

During or following its administration no toxic symptoms have been observed by the writers or their colleagues. In some cases the full dosage increases the diarrhea and causes a scalding sensation during defecation. These symptoms may be eliminated by reducing the dosage without discontinuing the treatment.

Anayodin alone is useless in the treatment of hepatic amoebiasis. When liver abscess is diagnosed present experience suggests that treatment with emetine hydrochloride hypodermically promptly carried out with the necessary precautions may stop further abscess extension. In such cases the administration of a full course of anayodin at the same time seems warranted to prevent later reinfection of the liver from the intestine.