The American Journal of Digestive Diseases

, Volume 2, Issue 9, pp 532–540 | Cite as

Influence on carbohydrate metabolism of experimentally induced hepatic changes

IV. Block of the reticulo-endothelial system with special reference to the Kupffer cell
  • T. L. Althausen
  • B. E. Blomquist
  • E. F. Whedon


Partial block of intravascular reticulo-endothelial cells causes lowering of the blood-sugar, increased tolerance to dextrose, decreased mobilization of blood-sugar by epinephrine and reduction in the glycogen content of the liver and muscles.

These findings are interpreted as indicating that one of the functions of the Kupffer cells is the transmission of precursors of glycogen from the blood stream to the liver. Block of these cells interferes with such a transfer and results in decreased gluconeogenesis and consequent internal deficiency of carbohydrates, which explains the observed abnormalities.

A review of available experimental data on the effects of reticulo-endothelial block in the metabolism of fats and proteins also suggests that this system acts as a transmitting agent of intermediary metabolities from the blood to the liver and perhaps to other organs rather than as a separate metabolic organ.


Kupffer Cell Muscle Glycogen Glycogen Content Hepatic Glycogen Colloidal Graphite 
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Copyright information

© Springer-Verlag 1935

Authors and Affiliations

  • T. L. Althausen
    • 1
  • B. E. Blomquist
    • 1
  • E. F. Whedon
    • 1
  1. 1.San Francisco

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