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Brain extracellular space: Some considerations on the role it plays in brain function

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Conditional reflex : a Pavlovian journal of research & therapy Aims and scope Submit manuscript

Abstract

The role of the extracellular space of the mammalian brain is reviewed. Special consideration is given to the question of ion accumulation in brain extracellular space. This issue is discussed in terms of the nerve theory of Hodgkin and Huxley. A brief review of this theory is included. Extracellular space is described not as a large unchanging compartment, but as a dynamic compartment in which ion concentrations are continuously changing. The consequences of some of these dynamic changes are discussedvis a vis altered brain states such as seizures and spreading depression.

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  1. Department of Physiology, University of Maryland School of Medicine, Baltimore, Maryland

    Allen P. Fertziger

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Fertziger, A.P. Brain extracellular space: Some considerations on the role it plays in brain function. Conditional Reflex 8, 178–186 (1973). https://doi.org/10.1007/BF03000497

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