Conclusions
1. The rectal mucous membrane can be passively and locally sensitized with human reagin-bearing sera.
2. The allergic reaction can be induced by either the oral or the rectal administration of the antigen.
3. The allergic reaction consists of edema, hyperemia, and increased mucous secretion.
4. Subjective symptoms, such as pruritis, burning, a sense of fullness, and a desire to empty the bowel, are commonly associated with the allergic reaction and vary with its location.
5. The allergic reaction in the sensitized mucous membrane of the gastro-intestinal tract may be induced by antigen which is in direct contact with it or by absorbed antigen which reaches it via the circulation or by both.
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References
Walzer, M., Sherman, H. and Feldman, L.: Studies in Mucous Membrane Hypersensitiveness. I. Passive Local Sensitization of the Ophthalmic Mucous Membrane.Jour. of Allergy, 6:215, 1935.
Sherman, H., Kaplan, C. and Walzer, M.: Studies in Mucous Membrane Hypersensitiveness. II. Passive Local Sensitization of the Nasal Mucous Membrane. In press.
Gray, I. and Walzer, M.: Studies in Absorption of Undigested Proteins in Human Beings. VI. The Absorption of Unaltered Protein from the Abnormal Gastro-Intestinal Tract.Amer. J. Digest. Dis. and Nutrit., 3:403, 1936.
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Read at the Annual Meeting of the American Gastro-Enterological Association, Atlantic City, June 7 and 8, 1937.
From the Division of Applied Immunology, Jewish Hospital of Brooklyn.
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Gray, I., Walzer, M. Studies in mucous membrane hypersensitiveness. American Journal of Digestive Diseases and Nutrition 4, 707–712 (1937). https://doi.org/10.1007/BF03000437
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DOI: https://doi.org/10.1007/BF03000437