Summary
Various degrees of polyposis of the colon were produced in 86 (34%) of a group of 250 rats fed diets including pulverized inert materials (kaolin, barium sulphate, talcum powder and pulverized cellulose). Bleeding of the colon occurred in about 90% of the 250 rats.
Intestinal stasis together with fecal conditions producing suction or traction upon the intestinal wall are believed to lead to the development of polyposis.
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References
Hoelzel, F. and Da Costa, E.: Production of ulcers in the prostomach of rats by protein restriction.Proc. Soc. Exper. Biol. and Med., 29:382, 1932.
Profound morphological changes following ulceration in the prostomach of rats.Proc. Soc. Exper. Biol. and Med., 29:385, 1932.
Experimental production of pylorospasm and gastric retention in rats.Jour. Exper. Med., 57:597, 1933.
Long, C. F., Kolmer, J. A. and Swalm, W. A.: Observations on intestines of rats fed inert materials.Jour. Lab. and Clin. Med., 20:475, 1935.
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From the Department of Physiology, University of Chicago.
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Hoelzel, F., Da Costa, E. Experimental production of polyposis of the colon in rats. American Journal of Digestive Diseases and Nutrition 4, 23–26 (1937). https://doi.org/10.1007/BF03000414
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DOI: https://doi.org/10.1007/BF03000414