Abstract
KCl water preference was examined in diet-replete, sodium-and sodium—potassium-deficient postpubertal rats of different ages. While diet-replete rats displayed a KCl preference-aversion profile similar to that found using other salts, when retested 30 days later, these same animals had no KCl preference. Na-and Na—K-deficient rats preferred KCl over a broad range of concentrations when tested in early postpuberty and the Na—K-deficient group had a markedly reduced KCl preference threshold (0.12%) when compared to all other groups in the study. But Na-and Na—K-deficient rats older by 2 1/2 months did not prefer KCl. The notion of specific food hungers can be invoked to account for some of the preferences. But hedonics, age and KCl experience must also be considered based on (1) the quantities of KCl consumed, (2) the preference reversals within animals, as well as (3) the significantly increased heart—and kidney—body weight ratios in the rats with the greatest KCl preference.
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References
Bare, J. K.: The specific hunger for sodium chloride in normal and adrenalectomized white rats.J. Comp. Physiol. Psychol.,42:242–253, 1949.
Blake, W. D. and Jurf, A. N.: Increased voluntary Na intake in K deprived rats.Commun. Behav. Biol.,1:1–7, 1968.
Brokaw, A.: Renal hypertrophy and polydipsia in potassium-deficient rats.Am. J. Physiol.,172:333–346, 1953.
Cleghorn, R. A. and McVicar, G. A.: High potassium diet and the survival of adrenalectomized rats.Nature,138:124, 1936.
Cullen, J. W., Scarborough, B. B. and Stager, G.: Calcium saccharin acceptability: Effects of concentration order and adaptation on consumption.Physiol. Behav.,5:621–624, 1970.
Follis, R.H., Orent-Keiles, E. and McCollum, E. V.: The production of cardiac and renal lesions in rats by a diet extremely deficient in potassium.Am. J. Pathol.,18:29–39, 1942.
Fregly, M. J.: Specificity of the sodium chloride appetite of adrenalectomized rats: Substitution of lithium chloride.Am. J. Physiol.,195:645–653, 1958.
Grunnert, R. R., Meyer, J. H. and Phillips, P. H.: The sodium and potassium requirements of the rat for growth.J. Nutr.,42:609–618, 1950.
Halstead, W. C. and Gallagher, B. B.: Autoregulation of amino acids intake in the albino rat.J. Comp. Physiol. Psychol.,55:107–111, 1962.
Harrison, H. E. and Darrow, D. C.: Renal function in experimented adrenal insufficiency.Am. J. Physiol.,125:631–643, 1939.
Lat, J.: Self-selection of dietary components. In C. F. Code (Ed.):Handbook of Physiol.ogy. Section 6. Alimentary Canal, vol. 1. Washington, D. C., American Physiol.ogical Society, 1967.
Meyer, J. H., Grunnert, R. R., Zepplin, M. T., Grummer, R. H., Bohstedt, G. and Phillips, P. H.: Effect of dietary levels of sodium and potassium on growth and on concentrations in blood plasma and tissues of white rat.Am. J. Physiol.,162:182–188, 1950.
Nachman, M. and Pfaffmann, C.: Gustatory nerve discharge in normal and sodium-deficient rats,J. Comp. Physiol. Psychol.,56:1007–1011, 1963.
Noble, R. L.: Physiology of the adrenal cortex. In G. Pincus and K. V. Thimann (Eds.):The Hormones, vol. 3. New York, Academic Press, 1955; p.p. 685–820.
Orent-Keiles, E. and McCollum, E. V.: Mineral metabolism of rats on an extremely sodium deficient diet.J. Biol. Chem.,133:75–81, 1940.
Orent-Keiles, E. and McCollum, E. V.: Potassium in animal nutrition.J. Biol. Chem.,140:337–352, 1941.
Pilgrim, F. J. and Patton, R. A.: Patterns of self-selection of purified dietary components by the rat.J. Comp. Physiol. Psychol.,40:343–348, 1947.
Richter, C. P.: The nutritional value of some common carbohydrates, fats, and proteins studied in rats by the single food choice method.Am. J. Physiol.,133:29–42, 1941.
Richter, C. P.: Total self-regulatory functions in animals and human beings.The Harvey Lecture Series,38:63–103, 1942.
Scott, E. M., Vemey, E. L. and Morissey, P. D.: Self-selection of diet; appetites for calcium, magnesium and potassium.J. Nutr.,41:187–201, 1950.
Stellar, E., Hyman, R. and Samet, S.: Gastric factors controlling waterand salt-sollution-drinking.J. Comp. Physiol. Psychol.,47:220–226, 1954.
Swingle, W. W. and Remington, J. W.: The role of the adrenal cortex in physiological processes.Physiol. Rev.,24:89–127, 1944.
Young, P. T.: Hedonic organization and regulation of behavior.Psychol. Rev.,73:59–86, 1966.
Zucker, J.: Short-term salt preference of potassium-deprived rats.Am. J. Physiol.,208:1071–1074, 1965.
Zwemer, R. L. and Truszkowski, R.: Potassium: A basal factor in syndrome of corticoadrenal insufficiency.Science,83:558–560, 1936.
Zwemer, R. L. and Truszkowski, R.: The importance of corticoadrenal regulation of potassium metabolism.Endocrinology,21:40–49, 1937.
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Cullen, J.W., Scarborough, D.E. Potassium chloride preference in normal, sodium—and sodium—potassium—deficient rats. Conditional Reflex 7, 151–163 (1972). https://doi.org/10.1007/BF03000214
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DOI: https://doi.org/10.1007/BF03000214