Abstract
Objective: The authors goal was to determine whether FDG uptakes in various regions of the brain are different for early and late scanning time in positron emission tomography (PET).Method: F-18 fluorodeoxyglucose (FDG) PET was performed on 15 healthy normal subjects to obtain early and late acquisition glucose metabolic images (30 and 60 min after FDG injection), respectively. The two sets of images were compared in a voxel-by-voxel analysis.Results: In the bilateral posterior cingulate gyrus, parietal and frontal association cortices, and subcallosal cortices, the FDG uptakes were larger on the late scan image than on the early scan image, and the FDG uptakes were larger in the cerebellar hemisphere, vermis and frontal basis on the early scan image than on the late scan image.Conclusions: These results suggest that there are different regional FDG uptakes depending on the scanning time after FDG injection and we must be careful in replacing conventional FDG PET scanning with early scanning in FDG PET study.
References
Kumar A, Braun A, Schapiro M, Grady C, Carson R, Herscovitch P. Cerebral glucose metabolic rates after 30 and 45 minute acquisitions: a comparative study.J Nucl Med 1992; 33: 2103–2105.
Ishii K, Sasaki M, Kitagaki H, Sakamoto S, Yamaji S, Maeda K. Regional difference of cerebral blood flow and oxidative metabolism in human cortex.J Nucl Med 1996; 37: 1086–1088.
Ishii K, Sasaki M, Kitagaki H, Yamaji S, Sakamoto S, Mori E. Reduction of cerebellar glucose metabolism in advanced Alzheimer’s disease.J Nucl Med 1997; 38: 925–928.
Iida H, Miura S, Kanno I, Murakami M, Takahashi K, Uemura K, et al. Design of evaluation of Headtome IV: a whole body positron emission tomograph.IEEE Trans Nucl Sci 1989; NS-37: 1006–1010.
Reivich M, Alavi A, Wolf A, Fowler J, Russell J, Anett C, et al. Glucose metabolic rate kinetic model parameter determination in humans: The lumped constants and rate constants for [18F] fluorodeoxyglucose and [11C] deoxyglucose.J Cereb Blood Flow Metab 1985; 5: 179–192.
Sasaki H, Kanno I, Murakami M, Shishido F, Uemura K. Tomographic mapping of kinetic rate constants in the fluorodeoxyglucose model using dynamic positron emission tomography.J Cereb Blood Flow Metab 1986; 6: 447–454.
Sakamoto S, Ishii K. Low cerebral glucose extraction rates in the human medial temporal cortex and cerebellum.J Neurol Sci 2000; 172: 41–48.
Fukuyama H, Kameyama M, Harada K, Nishizawa S, Senda M, Mukai T, et al. Glucose metabolism and rate constants in Alzheimer’s disease examined with dynamic positron emission tomography scan.Acta Neurol Scand 1989; 80: 307–313.
Minoshima S, Foster NL, Kuhl DE. Posterior cingulate cortex in Alzheimer’s disease.Lancet 1994; 344: 895.
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Ishii, K., Sakamoto, S., Hosaka, K. et al. Variation in FDG uptakes in different regions in normal human brain as a function of the time (30 and 60 minutes) after injection of FDG. Ann Nucl Med 16, 299–301 (2002). https://doi.org/10.1007/BF03000112
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DOI: https://doi.org/10.1007/BF03000112