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The effect of ephedrine on the secretion of acid by the human stomach

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The American Journal of Digestive Diseases

Summary and Conclusions

The effect of therapeutic doses of ephedrine sulphate (one grain, or 0.065 Gm.) was determined in three healthy male subjects. It was found that the ephedrine distinctly decreased both the total acidity and the free hydrochloric acid of the gastric juice.

In view of these findings, combined with the well established fact that ephedrine in therapeutic doses depresses gastric motility, it is suggested that this drug might find therapeutic application in the treatment of certain selected cases of uncomplicated gastric ulcer.

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Authors and Affiliations

  1. Morgantown, West Virginia

    M. A. Rafferty Ph.C., Edward J. van Liere M.D. & Clark K. Sleeth B.S.

Authors
  1. M. A. Rafferty Ph.C.
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  2. Edward J. van Liere M.D.
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  3. Clark K. Sleeth B.S.
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Additional information

From the Departments of Biochemistry and Physiology, West Virginia University, Morgantown, W. Va.

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Rafferty, M.A., van Liere, E.J. & Sleeth, C.K. The effect of ephedrine on the secretion of acid by the human stomach. American Journal of Digestive Diseases and Nutrition 4, 366–368 (1937). https://doi.org/10.1007/BF02999934

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  • DOI: https://doi.org/10.1007/BF02999934

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