Summary
1. This method is simple, accurate and rapid. It can easily be used as an office procedure.
2. It is extremely sensitive, as small amounts of pepsin may be detected.
3. Peptic activity apparently seems to run parallel to HCl secretion in all cases except those in the Achylia group.
4. In Achylia gastrica, it seems that pepsinogen or pepsin is still secreted despite the fact that HCl is not present.
5. Meat usually produces a definite increase in peptic activity in all groups except the achylias.
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References
Aaron, A. H., Bockus, H. L. and Ivy, A. C.: Report of Committee “On Survey of Enzyme Tests as Performed by Members of American Gastro-Enterological Association.”Am. J. Dig. Dis. and Nutrit., 1:268, Sept., 1934.
Rose, W. C.: A Modified Method for the Clinical Estimation of Pepsin.Arch. Int. Med., 5:459, May, 1910.
Anson, M. L. and Mirsky, A. E.: The estimation of pepsin with hemoglobin.J. Gen. Physiol., 16:59, Sept. 20, 1932.
Gilman, A. and Cowgill, G. R.: The determination of peptic activity: An examination and application of the Gates Method of proteolytic enzyme titration.J. Biol. Chem., 88:743, Oct., 1930.
Northrop, J. H.: Pepsin Activity Units and Methods for Determining Peptic Activity.J. Gen. Physiol., 16:41, Sept. 20, 1932.
Holter, H. and Andersen, B.: Vergleich der Pepsin- und Labaktivität verschiedener Magensekrete.Biochem. Z., 269:285, 1934.
Discussed by Tauber, H.: Enzyme Chemistry. John Wiley and Sons, Inc., New York, 1937.
Ege, R. and Menck-Thygesen, P.: Uber die Aktivierung des Propepsins.Biochem. Z., 264:13, 1933.
Bockus, H. L., Bank, J. and Willard, J. H.: Achlorhydria with a Review of 210 Cases in Patients with Gastro-intestinal Complaints.Amer. J. Med. Sci., 184:185, 1932.
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From the Departments of Gastro-Enterology and of Physiology and Biochemistry, New York Medical College and Flower Hospital, New York City.
An erratum to this article is available at http://dx.doi.org/10.1007/BF02999974.
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Barowsky, H., Tauber, H. & Kleiner, I.S. An office procedure for the rapid estimation of pepsin and its clinical significance. American Journal of Digestive Diseases and Nutrition 4, 229–231 (1937). https://doi.org/10.1007/BF02999903
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DOI: https://doi.org/10.1007/BF02999903