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Urinary Excretion of Silica in Humans Following Oral Administration of Magnesium Trisilicate

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The American Journal of Digestive Diseases

Conclusions

  1. 1.

    Urinary silica excretion studies were carried out on five healthy, male subjects on regular diets and the mean twenty-four-hour excretion was found to be 16.2 mg. of silica.

  2. 2.

    The urinary excretion of silica varied widely and was proportional to the amount of silica in the diet.

  3. 3.

    Urinary silica excretion was increased in healthy subjects when magnesium trisilicate was taken by mouth.

  4. 4.

    These studies suggest that silica, is excreted by the kidneys in direct proportion to the amount absorbed and that there is probably no definite renal threshold for silica.

  5. 5.

    No evidence has been found that the administration of magnesium trisilicate by mouth has any deleterious effect on the human or animal organism.

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References

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Author information

Authors and Affiliations

  1. The Division of Internal Medicine and the Laboratory, Grasslands Hospital, Valhalla, New York

    Andrew Frey

  2. New York, New York

    Robert C. Page

  3. New Rochelle, New York

    Reid R. Heffner

Authors
  1. Robert C. Page
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  2. Reid R. Heffner
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  3. Andrew Frey
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Additional information

The preparation used in this study was ’Tabloid’ Magnesium Trisili-cate, gr. 7%, furnished by Burroughs Wellcome & Co., New York.

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Page, R.C., Heffner, R.R. & Frey, A. Urinary Excretion of Silica in Humans Following Oral Administration of Magnesium Trisilicate. Jour. D. D. 8, 13–15 (1941). https://doi.org/10.1007/BF02999386

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  • DOI: https://doi.org/10.1007/BF02999386

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