Prophylactic treatment of peptic ulcers produced experimentally by cinchophen

Summary and Conclusions

Some benefit was found from a diet of milk alone and from the use of a duodenal extract in the prophylactic treatment of peptic ulcers produced experimentally by the administration of cinchophen. Mucin appeared to be definitely beneficial in some cases but in others a chronic ulcer developed similar to those found in control animals fed cinchophen without prophylactic treatment. A chronic lesion was not produced in the presence of alkali-milk diet therapy. No benefit was observed from intramuscular injections of histidine monohydrochloride.

In none of the animals subjected to gastro-enterostomy did gastric, duodenal, or jejunal ulcers develop. A jejunal ulcer frequently developed, however, when pyloric or gastric exclusion had been performed. No lesions were observed in the isolated pyloric segment of the stomach, although definite ulceration occurred when acid-secreting mucosa was included in the isolated portion of the stomach.

From these observations and from studies of gastric secretion it would appear that gastric acidity is a factor in the experimental production of peptic ulcers by administration of cinchophen.