Skip to main content
SpringerLink
Log in

III. The rate of absorption of salicylates and the effect of certain compounds on the rate of absorption of acetylsalicylic acid from the stomach and intestine

  • Therapeutics
  • Published:
The American Journal of Digestive Diseases

Conclusions

1. Salicyl compounds are readily absorbed from the stomach.

2. Gastric absorption is more rapid with the smaller salicyl molecules and at lower pH’s.

3. Calcium gluconate which does not materially affect the pH of the acetylsalicylic acid solution likewise does not affect the rate of gastric absorption.

4. Sodium bicarbonate and magnesium oxide which raise the pH of the solution inhibit the rate of gastric absorption of acetylsalicylic acid.

5. The rate of intestinal absorption of salicyl compounds is less affected by the pH of the solution than is their rate of gastric absorption.

6. Substances used to protect against gastro-intestinal irritation, such as calcium gluconate, sodium bicarbonate, and magnesium oxide, do not markedly influence the rate of intestinal absorption of acetylsalicylic acid.

7. Sodium salicylate, calcium salicylate and salicylic acid are absorbed from the intestine at a faster rate than is acetylsalicylic acid.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Burow:Med. Klin., 7:341, 1911.

    CAS  Google Scholar 

  2. Brequet:Zentr. Biochem. Biophys., 14:601–2, 1912.

    Google Scholar 

  3. Houghton:Am. J. Physiol., 13:331, 1905.

    CAS  Google Scholar 

  4. Delhougne:Arch. Exp. Path. and Pharmak., 159, 128, 1931.

    Article  Google Scholar 

  5. Pinczower:Therap. Monatschf., 24:297, 1910.

    Google Scholar 

  6. Blume and Nohara:Arch. Exp. Path. Pharmakol., 173, 413–30, 1933.

    Article  CAS  Google Scholar 

  7. Lim, Ivy and McCarthy:Quart. J. Exp. Physiol., 15:13, 1925.

    CAS  Google Scholar 

  8. Thoburn and Hanzlik:J. Biol. Chem., 23:163, 1915.

    CAS  Google Scholar 

  9. Seidell:J. Am. Chem. Soc., 31, 1169, 1909.

    Google Scholar 

  10. Bradley:Proc. Soc., Oct., 1936.

Download references

Author information

Authors and Affiliations

  1. Chicago, Illinois

    W. B. Bradley M.D., J. G. Schnedorf M.D. & A. C. Ivy M.D.

Authors
  1. W. B. Bradley M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. J. G. Schnedorf M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. A. C. Ivy M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

From the Department of Physiology and Pharmacology, Northwestern University Medical School, Chicago, Illinois.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Bradley, W.B., Schnedorf, J.G. & Ivy, A.C. III. The rate of absorption of salicylates and the effect of certain compounds on the rate of absorption of acetylsalicylic acid from the stomach and intestine. American Journal of Digestive Diseases and Nutrition 3, 415–419 (1936). https://doi.org/10.1007/BF02999164

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02999164

Keywords

Search

Navigation