Conclusions
1. Normal serum always contains serum amylase, lipase and protease, in a constant concentration of 0.2 by the test which we have suggested.
2. We believe we have shown that the serum enzymes are in fact, pancreatic enzymes.
3. When given by mouth, the pancreatic enzymes are absorbed in the active state.
4. The normal concentration of serum enzymes cannot be increased by the administration of pancreatic enzymes.
5. Pancreatic hypofunction is quickly corrected by the administration of an active extract of whole pancreas.
6. When given in excessive dosage, pancreatic extract seems to be stored in the liver and spleen, from which organs it is liberated in such concentration as to maintain the normal serum level.
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References
Oelgoetz, A. W., Oelgoetz, P. A., Wittekind, J.Amer. Jour. Digest. Dis. and Nutrit., Dec. 1934.
Oelgoetz, A. W., Oelgoetz, P. A., Wittekind, J.Amer. Jour. Digest. Dis. and Nutrit., Sept. 1935.
Elman, R. and McCaughan, J. M.Arch. Int. Med., 40;58, 1927.
Zucker, T. F., Newberger, P. G., and Berg, B. N.Amer. Jour. Physiol., 102, 209., 1932.
Crandall, L. A.Amer. Jour. Digest. Dis. and Nutrit., April, 1935.
Baxter, S. G.,Amer. Jour. Digest. Dis. and Nutrit., April, 1935.
Oelgoetz, A. W., Oelgoetz, P. A. and Wittekind, J.Medical Record. January, 1936.
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Oelgoetz, A.W., Oelgoetz, P.A. & Wittekind, J. The origin, fate and significance of the serum enzymes. American Journal of Digestive Diseases and Nutrition 3, 159–161 (1936). https://doi.org/10.1007/BF02999100
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DOI: https://doi.org/10.1007/BF02999100