Summary
Aluminum hydroxide, aluminum phosphate and aluminum chloride inactivate pepsin even at a pH as low as 1.0 to 2.0. This is due in part to the inhibition of peptic digestion by aluminum ions. Magnesium trisilicate does not inactivate pepsin at such pH levels.
The order of efficacy of these compounds by weight at pH 1.0 to 2.0 is: (1) A12(OH)6, (2) A1PO4, (3) A1C13, (4) Mg2Si3O8 25H2O.
When the pH is higher than 2.0, precipitation of pepsin by A12(OH)6 and A1PO4 takes place. At such pH levels A12(OH)6 is considerably more effective than A1PO4.
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References
Fauley, G. B., Ivy, A. C, Terry, L. and Bradley, W. B.:Am. J. Dig. Dis., 5:792, 1939.
Fauley, G. B., Freeman, S., Ivy, A. C, Atkinson. A. J. and Wigodsky, H. S.: Made available to us in manuscript (1940).
Komarov, S. A. and Komarov, O.:Am. J. Dig. Dis., 7:166, 1940.
Schiffrin, M. J.:Proc. Soc. Exp. Biol. and Med., 45:592, 1940.
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The preparations used in this study were: Amphojel, containing about 6% A12(OH)6; Aluminum Phosphate Gel, containing 4% A1PO4; and magnesium trisilicate, Mg2Si3O6 25H2O. All the above reagents were supplied through the courtesy of John Wyeth & Brother, Inc.
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Schiffrin, M.J., Komarov, S.A. The inactivation of pepsin by compounds of Aluminum and Magnesium. American Journal of Digestive Diseases 8, 215–217 (1941). https://doi.org/10.1007/BF02998404
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DOI: https://doi.org/10.1007/BF02998404