Skip to main content
SpringerLink
Log in

Action of histaminase preparations in the heidenhain dog

  • Published:
The American Journal of Digestive Diseases

Summary

Preparations of histaminase from hog kidney, having potencies of at least one unit per mg of protein were found to be highly toxic when injected intravenously into dogs in amounts above 300 mg. The toxicity apparently was not due to histaminase itself because a preparation of histaminase, which had been inactivated, was found to be even more toxic per mg of protein.

The toxic symptoms observed were trembling of extremities, coldness, ischemia of the gastric mucosa, vomiting, and defecation. This condition prevented normal activity of the gastric mucosa, and therefore made it impossible to use the inhibition of gastric secretion as an assay of the activity of histaminasein vivo, at least in the present state of purification of histaminase.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

Reference

  1. Laskowski, M., Lemley, J. M., and Keith, C. K.: Arch. Biochem. 1945,6, 105.

    CAS  Google Scholar 

  2. Lemley, J. M., and Laskowski, M.: Arch. Biochem., ibid., 1945,6, 115.

    CAS  Google Scholar 

  3. Necheles, H., and Olson, W. H.: Am. J. Dig. Dis., 1941,8, 217.

    CAS  Google Scholar 

  4. Atkinson, A. J., Ivy, A. C., and Bass, V.: Am. J. Physiol., 1941,132, 51.

    CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. The Departments of Physiology and Physiological Chemistry School of Medicine, University of Arkansas, Little Rock, Ark.

    H. H. Rostorfer & M. Laskowski

Authors
  1. H. H. Rostorfer
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. M. Laskowski
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Rostorfer, H.H., Laskowski, M. Action of histaminase preparations in the heidenhain dog. Jour. D. D. 12, 337–339 (1945). https://doi.org/10.1007/BF02998368

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02998368

Keywords

Search

Navigation