Summary
-
1.
A series of dogs in one group were fed “yellow” cinchophen; each dog developed peptic ulceration, which was indistinguishable from peptic ulcer in humans.
-
2.
A series of control dogs in another group was also fed yellow cinchophen in exactly the same way, but in addition, the dogs were fed a mucosal and submucosal preparation from the hog’s stomach and duodenum.
-
3.
The dogs in the group which were fed the hog stomach and duodenal preparation with cinchophen did not develop peptic ulcers as did the dogs in the group who were fed the cinchophen alone.
-
4.
It is suggested from these preliminary experiments that some support is present for the previously reported belief of the author that a “protective principle” is elaborated by the human gastric mucosa and that this “protects” the stomach from self-digestion, and ulcer formation.
-
5.
A “protective principle” may also be contained in the mucosa of the hog’s stomach and duodenum which was effective in preventing peptic ulcers in dogs whose controls had induced peptic ulcers indistinguishable from human peptic ulcers.
Similar content being viewed by others
References
Morrison, L. M.: Peptic Ulcer Disappearance Following Feedings of Normal Gastric Juice. Amer. Jour. Digest. Dis. 12:323, Oct. 1945.
Churchill, T. P., and Van Wagoner, F. H.: Cinchophen Poisoning, Proc. Soc. Exper. Biol. and Med. 28:581–582 (Mar.) 1931.
Van Wagoner, F. H., and Churchill, T. P.: Production of Gastric and Duodenal Uucers in Experimental Cinchophen Poisoning in Dogs; Arch. Path. 14: 860–969 (Dec.) 1932.
Bollman, J. L., and Mann, F. C.: Experimental Production of Gastric Ulcers, Pro. Staff Meet Mayo Clinic. 10:580–582 (Sept. 11) 1935.
Stalker, L. K., Bollman, J. L., and Mann, F. C.: Experimental Peptic Ulcer Produced by Cinchophen; Methods of Production. Arch. Surg. 35: 290 (Aug.) 1937.
Simonds, J. P.: Mode of Origin of Experimental Gastric Ulcer Produced by Cinchophen, Arch. Path. 26:44 (July) 1938.
Schwartz, S. O., and Simonds, J. P.: Peptic Ulcers Produced by Feeding Cinchophen to Mammals Other than the Dog. Proc. Soc. Exper. Biol. and Med. 32: 1138–1134, 1935.
Cheney, G.: Cinchophen Gastric Ulcers in Chicks. Arch. Int. Med. 70: 532–557, (Oct.) 1942.
Hanke, Hans: Experimental Production of Acute Ulcerative Gastritis by Parenteral Administration of Atophenyl. Internat. Clinics. 1: 233–236, (Mar.) 1935.
Reah, T. G.: Cinchophen Poisoning, Lancet 2:504, 1932.
Bloch, L., and Rosenberg, D. H.: Gastric Ulcers Associated with Cinchophen Poisoning, Amer. Jour. Digest. Dis. and Nutrition 1:29, 1934.
Stalker, L. K., Bollman, J. L., and Mann, F. C.: Prophylactic Treatment of Peptic Ulcers Produced Experimentally by Cinchophen, Amer. Jour. Digest, and Nut. 3:822, (Jan.) 1937.
Rivers, A. B.: The Use of Duodenal Extract as an Adjuvant in the Treatment of Benign Peptic Lesions. Amer. Jour. of Digest. Dis. and Nut. 2:189, (May) 1935.
Schmassman, Hector: Ueber die interne Behandlung des Ulcers Ventriculi and Ulcers duodeni mit den Magendiinndarmpraparaten Robuden. Schweiz Med. Wchnschr. 74:576, (May 27) 1944.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Morrison, L.M. 2. The prevention of induced peptic ulcer in dogs by feeding a hog stomach preparation. Jour. D. D. 12, 328–330 (1945). https://doi.org/10.1007/BF02998366
Issue Date:
DOI: https://doi.org/10.1007/BF02998366