Conclusions
Inositol markedly increases the peristalsis of the stomach and the small intestine. Nicotinic acid decreases the peristaltic action of the stomach and small intestine. The other members of the B complex available in pure form, thiamine, riboflavin, choline, pyri-doxine and pantothenic acid, have no apparent action of this type.
Inositol and nicotinic acid are the members of the Vitamin B complex directly concerned with gastrointestinal motility, and it is suggested that the balance or ratio of nicotinic acid or similar compounds to inositol is the nutritional factor which determines hypo- or hypermotility.
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References
Norris, Earl R. and Hauschildt, J.: A New Factor of the Vitamin B Complex Required by Albino Mouse.Science, 92:316, 1940.
Woolley, D. W.: A New Dietary Essential for the Mouse.J. Biol. Chem., 136:113, 1940.
Martin, Gustav J. and Hueper, W. C. : The Mouse Anti-alopecia Factor. (In press).
Woolley, D. W.: The Nature of the Anti-alopecia Factor.Science, 92:384, 1940.
Eastcott, Edna V.: Wilder’s Bios. Isolation and Identification of Bios I.J. Phys. Chem., 32:1094, 1928.
Anderson, R. J. and Bosworth, A. W.: Utilization of Inositol in Animal Organism. Effect of Inositol on Metabolism of Man.J. Bio. Chem., 25:399, 1916.
Burns, David: Note on Effect of Purgation on the Creatinine Content of Urine.Biochem. J., 14:94, 1920.
Cowgill, G. R.: The Vitamin B Requirement of Man. Yale U. Press, New Haven, 1934.
Cowgill, G. R.: Studies in Physiology of Vitamins.Proc. Soc. Exp. Bio. and Med., 18:148, 1921.
Cowgill, G. R. and Gilman, A. Z.: Vitamins—Effect of Lack of Vitamin B Complex on Secretion of Gastric Juice.Arch. Int. Med., 53:58, 1934.
Alvarez, W. C, Pilcher, F., Foley, M. A., Mayer, A. and Osterberg, A. E.: The Effects on Gastric Juice of Deprivation of Vitamin B,.Am. J. Dig. Dis. and Nutrit., 3:102, 1937.
Sure, B. and Harrelson, R. T.: Enzymic Efficiency in Avitami- nosis.Am. J. Dig. Dis. and Nutrit., 4:177, 1937.
Williams, R. R. and Spies, T. D.: Vitamin B,. MacMillan, N. Y., 1938.
Sparks, M. I. and Collins, E. N.: The Role of Vitamin B, in the Tonus of Large Intestines.Am. J. Dig. Dis. and Nutrit., 2 :618, 1935.
Babkin, B. P.: The Physiological Factors Det. Acidity of Gastric Juice and Gastric Contents.Canad. M. A. J., 29:5, 1933.
Chatterjee, D. D.: Intestinal Motility in Avitaminosis B and in Starved Animals.Indian J. M. Research, 23:191, 1935.
Molitor, H. and Sampson, W. L. : Quoted AnnualRev. of Biochemistry.
Elsom, K. O’Shea, Lewy, F. H. and Heublein, G. W.: Clinical Significance of Exp. Human Vitamin B Complex Deficiency.Am. J. Med. Sci., 200:757, 1940.
Pendergrass, E. P. and Comroe, B. I.: Roentgen Study of Gastro-Intestinal Tract in Chronic Idiopathic Adult Tetany.Am. J. Roent., 33:647, 1935.
Mackie, T. T. and Pound, R. E.: Changes in Gastro-Intestinal Tract in Deficiency States.J. A. M. A., 104:313, 1935.
Snell, A. M. and Camp, J. D.: Chronic Idiopathic Steatorrhea, Roentgenological Observations.Arch. Int. Med., 53:615, 1934.
Crandall, L. A., Chesley, F. F., Hansen, D. and Dunbar, J.: The Relation of P-P Factor to Gastro-Intestinal Motility.Proc. Soc. Exper. Biol. and Med., 41 :472, 1939.
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Martin, G.J., Thompson, M.R. & De Carvajal-Forero, J. The influence of inositol and other B complex factors upon the motility of the gastro-intestinal tract. American Journal of Digestive Diseases 8, 290–295 (1941). https://doi.org/10.1007/BF02998327
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DOI: https://doi.org/10.1007/BF02998327