The American Journal of Digestive Diseases

, Volume 8, Issue 4, pp 124–128 | Cite as

The effect of feeding apple sauce on induced diarrhea in rats

  • Z. I. Kertesz
  • Martha S. Walker
  • C. M. McCay


  1. 1.

    Rats fed on a diet of 10 cc. of milk containing 1 g. lactose per day developed diarrhea which, in most cases, was maintained for several days.

  2. 2.

    When apple sauce was fed to the rats after the diarrhea persisted for three days, the great majority of the animals were cured. The “efficiency” of the apple sauce in curing the diårrhea was rated at 84 per cent.

  3. 3.

    Apple sauce in which the pectins were digested by enzymes showed an “efficiency” of 39 per cent only, indicating the important role of pectins in the therapeutic action.

  4. 4.

    The residue obtained after enzyme digestion and exhaustive water extraction of the apple sauce and containing almost exclusively “crude fiber” showed definite curative action, indicating that materials other than the pectins also contributed to the curative action of the apple sauce.

  5. 5.

    An evaluation of the results indicates that, in the present case at least, the curative effect of the apple sauce depended on the pectins and fibrous materials responsible for its colloidal properties. There was no indication that the presence of uronic acids had any role in curing the induced diarrhea in rats.



Diarrhea Lactose Pectin Crude Fiber Galacturonic Acid 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    American Medical Ass’n, Council on Foods.J. A. M. A., 109: 1636, 1937.Google Scholar
  2. 2.
    Bergeim, Olaf:J. Biol. Chem., 62:49, 1924-25.Google Scholar
  3. 3.
    Carrù, M. H. and Haynes, D.:Biochem. J., 16:60, 1922.Google Scholar
  4. 4.
    Cori, F.:J. Biol. Chem., 66:691, 1925.Google Scholar
  5. 5.
    Cowdry, E. V.: Problems in Aging. The Williams and Wilkins Co., Baltimore, 1939.Google Scholar
  6. 6.
    Fischer, E. A.:New Zealand J. Sci. and Techn., 13:96, 1931. (Cited afterNutr. Abstr. and Rev.).Google Scholar
  7. 7.
    Gebhardt, W.:Klin. Wochenschr., 14:1459, 1935.CrossRefGoogle Scholar
  8. 8.
    Imhäuser, K.:Arch. Exp. Path. Pharm., 167:702, 1932.CrossRefGoogle Scholar
  9. 9.
    Kertesz, Z. I.:J. Nutrii., 20:289, 1940.Google Scholar
  10. 10.
    Kertesz, Z. I. and Loconti, J. D.: In press.Google Scholar
  11. 11.
    Koehler, A. E. and Allan, S. E.:J. Nutrit., 8:377, 1934.Google Scholar
  12. 12.
    Malyoth, G.:Klin. Wochenschr., 13:51. 1934.CrossRefGoogle Scholar
  13. 13.
    Mitchell, H. S., Cook, G. M. and O’Brien, K. L.:J. Biol. Chem., 128:LXXI, 1939.Google Scholar
  14. 14.
    Parsons, H. T.:J. Biol. Chem., 90:361, 1931.Google Scholar
  15. 15.
    Parsons, H. T. and Kelly, E.:Am. J. Physiol., 104:150, 1933Google Scholar
  16. 16.
    Robertson, E. and Doyle, M. E.:J. Nutrit., 9:553, 1935.Google Scholar
  17. 17.
    Schoenemann, R.:Landw. Versuchsstat., 128:1, 1934.Google Scholar
  18. 18.
    Voss, E. A.:Zeitschr. Kinderheilkunde, 59:391, 1935.CrossRefGoogle Scholar
  19. 19.
    Whittier, E. O., Cary, C. A. and Ellis, N. R.:J. Nutrit., 9:521, 1935.Google Scholar

Copyright information

© Springer 1941

Authors and Affiliations

  • Z. I. Kertesz
    • 1
  • Martha S. Walker
    • 2
  • C. M. McCay
    • 2
  1. 1.Division of ChemistryNew York State Agricultural Experiment StationGeneva
  2. 2.Department of Animal NutritionCornell UniversityIthaca

Personalised recommendations