The effect of feeding apple sauce on induced diarrhea in rats
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Rats fed on a diet of 10 cc. of milk containing 1 g. lactose per day developed diarrhea which, in most cases, was maintained for several days.
When apple sauce was fed to the rats after the diarrhea persisted for three days, the great majority of the animals were cured. The “efficiency” of the apple sauce in curing the diårrhea was rated at 84 per cent.
Apple sauce in which the pectins were digested by enzymes showed an “efficiency” of 39 per cent only, indicating the important role of pectins in the therapeutic action.
The residue obtained after enzyme digestion and exhaustive water extraction of the apple sauce and containing almost exclusively “crude fiber” showed definite curative action, indicating that materials other than the pectins also contributed to the curative action of the apple sauce.
An evaluation of the results indicates that, in the present case at least, the curative effect of the apple sauce depended on the pectins and fibrous materials responsible for its colloidal properties. There was no indication that the presence of uronic acids had any role in curing the induced diarrhea in rats.
KeywordsDiarrhea Lactose Pectin Crude Fiber Galacturonic Acid
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