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Inhibitory effect of glycyrrhiza uralensis fish and chelidonium majus L on gastrocarcinogenesis induced by N-methyl-N′-nitron-N-nitrosoguanidine

  • Basic Investigation
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Chinese Journal of Cancer Research

Abstract

In order to investigate the antagonistic effect of Glycyrrhiza Uralensis Fish (GUF) and Chelidonium maJus L (CML) on gastrccarcinogenesis induced by MNNG in Wastar rats, we treated the rats with MNNG alone (group 1) and with MNNG plus GUF and CML (group 2 and 3) respectively. The incidence of infiltrating adenocarcinoma of the glandular stomach and duodenum in group 2 was significantly lower than that in group 1 (26.7% vs. 67.8%). The differentiation and aggressivenees of carcinomas occured in group 2 were much better and mild than those in group 1. Present study also demonstrated that the inhibitory effect of CML on proliferation of human stomach carcinoma cell line MGC-803 was very remarkable; in addition, GUF and CML were able to antagonise the mutagenic activation of MNNG. These results suggest that GUF and CML may be empoyed in prevention of gastric carcinoma.

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References

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Authors and Affiliations

  1. Department of Pathology, Beijing Institute for Cancer Research, China

    Li Jiyou, Xie Yuquan & Wang Mingsheng

  2. Department of Etiology, Beijing Institute for Cancer Research, China

    Shi Guizhi, Sun Heling & Ji Xinhua

  3. Laboratory of Gastric Disease, Beijing Institute for Cancer Research, China

    Jin Maolin & Yang Boqin

Authors
  1. Li Jiyou
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  2. Xie Yuquan
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  3. Shi Guizhi
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  4. Sun Heling
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  5. Ji Xinhua
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  6. Jin Maolin
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  7. Yang Boqin
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  8. Wang Mingsheng
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Li, J., Xie, Y., Shi, G. et al. Inhibitory effect of glycyrrhiza uralensis fish and chelidonium majus L on gastrocarcinogenesis induced by N-methyl-N′-nitron-N-nitrosoguanidine. Chin J Cancer Res 4, 10–12 (1992). https://doi.org/10.1007/BF02997502

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  • DOI: https://doi.org/10.1007/BF02997502

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