Abstract
Zinc sulfonated phthalocyanine (ZnSPc) 10–20 mg/kg plus light showed strong inhibition on mouse S-180 and RA795 lung carcinoma, inhibition rate was 44.8% and 57.4% respectively. Aluminum sulfonated phthalocyanine (AlSPc) 20 mg/kg plus copper vapor laser or red light, tumor inhibition rate of S-180 was 62.7% and 66.8% respectively, AlSPc 1.25 µg/ml caused severe photohemolyses of red cells. At the dose of 10 µg/ml plus light, lipid peroxidation of red cell membrane was greatly enhanced. Acetylchollnesterase (AchEs) of red cell membrane inactivated, liver mitochondrial ATPase and microsomal G-6-Pase inhibited. ZnSPc at the dose of 1.25 µg/ml caused obvious photodamage on DNA of hepatoma cells.
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Fu, N., Quan, L., Yan, L. et al. Photodynamic and photobiological action of sulfonated phthalocyanines. Chin J Cancer Res 4, 1–5 (1992). https://doi.org/10.1007/BF02997500
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DOI: https://doi.org/10.1007/BF02997500