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Depletion of O6-methylguanine-DNA methyltransferase activity and potentiation of 1-(4-amino-2-methyl-5-pyrimidinyl) methyl-3 (2-chloroethyl)-3-nitro-sourea antitumor effect by streptozotocin

  • Basic Investigations
  • Published:
Chinese Journal of Cancer Research

Abstract

O6-methylguanine-DNA Methyltransferase (MGMT) can specifically repair the DNA demage induced by chloroethylnitrosoureas (CENU) such as 1-(4-amino-2-mcthja-pyrimidinyl) methyl- 3- (2- chloroethyl)- 3-nitrosourea (ACNU), constituting the molecular basis of tumor cell resistance to CENU. The present study demonstrated that sensitization of resistant tumor cells to ACNU could be achieved by streptozotocin (STZ) treatment which could deplete MGMT activityin vitro andin vivo. It suggested that depletion of the molecular basis of tumor cell resistance to chemotherapeutic agents might be a practicable way to improve the effectiveness of tumor chemotherapy.

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Chen, J., Zhang, Y., Sui, J. et al. Depletion of O6-methylguanine-DNA methyltransferase activity and potentiation of 1-(4-amino-2-methyl-5-pyrimidinyl) methyl-3 (2-chloroethyl)-3-nitro-sourea antitumor effect by streptozotocin. Chin J Cancer Res 5, 48–52 (1993). https://doi.org/10.1007/BF02997493

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